CALCULATING PENETRANCE FOR ALS CASES

*** Please Note: the estimate is weighted by the proportion of UK families of size 1,2,..5

Proportion of FALS   %
Percentage of fALS carrying variants e.g. 45  %
Percentage of sALS carrying variants e.g. 7  %    




Al-Chalabi A, Lewis CM. Modelling the effects of penetrance and family size on rates of sporadic and familial disease.
Hum Hered. 2011;71(4):281-8. doi: 10.1159/000330167