1) There are currently six web pages under the analysis menu: Detailed
analysis, Interactions, Side-by-side comparison, Predict pathogenicity, Gene
credibility and Interactive Molecular stucture.
2) Clicking on the Detailed analysis submenu, an automatically populated
checkbox list of genes with patient data, two dropdownlists on age of onset
range (in years) from 0 to 100 and radiobuttons for further selections on
gender, inheritance type and site of onset.
3) Clicking on the Interactions submenu, a checkboxlist of all available genes in
ALS are displayed. A group of checkboxes dynamically derived from the gene table
is displayed to allow users select as many gene interactions they would like to
analyse. Once the genes are selected, the list is presented as confirmation. The
“Execute” link is clicked to display the prediction on the same page. If the
“Reset” link is clicked, all the selected boxes are automatically deselected and
the graphical analysis is cleared to allow for fresh analysis.
4) Clicking on the Side-by-side submenu, runs a query analysis on genetic data
displaying 4 dropdownlists to select any two genes and the age range of
patients. A side-by-side comparison of mutation and patient data on two selected
genes is submitted to the database. The query is analysed and displayed
graphically on the website automatically in a split of a second. It shows the
site of onset, mean age using box plot, gender, family history, nationalities of
patients and other joint analysis of both genes.
5) Clicking on the Predict pathogenicity submenu, a list of genes are
automatically pooled from the database based on the availability of genes with
at least a substitution mutation.
6) Clicking on the Gene credibility submenu, 11 checkboxes appear as
6) Clicking on the Molecular structure displays an interactive image for users to view by right clicking on the image.