GENE OVERVIEW OF ANIMAL MODEL


GeneSod1
Gene Namesuperoxide dismutase 1, soluble
Organism Namerat
Biological NameRattus norvegicus
Other NamesCuZnSOD
ChromosomeChr11 q11
Genomic coordinates 


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ALL PUBLICATIONS (114)

First_AuthorYearTitle
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Agbas2007Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo.
Ahtoniemi2008Mutant SOD1 from spinal cord of G93A rats is destabilized and binds to inner mitochondrial membrane.
Al-Kateb2007Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study.
Al-Majed2007Nimesulide prevents oxidative stress damage following transient forebrain ischemia in the rat hippocampus.
Asimakis2002Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts.
Bertinato2003Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats.
Boulos2007"Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury."
Carlstr+Âm2009SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis.
Carmeli2010Expression of superoxide dismutase and matrix metalloproteinase type 2 in diaphragm muscles of young rats.
Cassina2008Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.
Chan2006Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats.
Chang2002Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase.
Chaves2007Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension.
Chen2008Identifying stable reference genes for evaluation of antioxidative enzyme gene expression in auditory cortex and cochlea of young and old Fischer 344 rats.
Chen2007Reperfusion liver injury-induced superoxide dismutase and catalase expressions and the protective effects of N-acetyl cysteine.
Chen2012SOD1 aggregation in astrocytes following ischemia/reperfusion injury: a role of NO-mediated S-nitrosylation of protein disulfide isomerase (PDI).
Cheng2006Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients.
Colak2005Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications.
Comai2006"Influence of age on Cu/Zn-superoxide dismutase and indole 2,3-dioxygenase activities in rat tissues."
Crispino2004MPA inhibits idarubicin activity on Cu-Zn SOD and catalase.
Cullen2002Expression of antioxidant enzymes in diseases of the human pancreas: another link between chronic pancreatitis and pancreatic cancer.
Dakshayani2002Ornithine alpha-ketoglutarate modulates the levels of antioxidants and lipid peroxidation products in ammonium acetate treated rats.
Danielisov+í2007Activities of endogenous antioxidant enzymes in the cerebrospinal fluid and the hippocampus after transient forebrain ischemia in rat.
de2008Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats.
Delabar1987Cloning and sequencing of a rat CuZn superoxide dismutase cDNA. Correlation between CuZn superoxide dismutase mRNA level and enzyme activity in rat and mouse tissues.
Di2005Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis.
Durand2011Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries.
Elchuri2004CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Faiz2006Antioxidant Cu/Zn SOD: expression in postnatal brain progenitor cells.
Filipovi-ç2009Acute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liver.
Filipovi-ç2009Differential regulation of CuZnSOD expression in rat brain by acute and/or chronic stress.
Flekac2008Gene polymorphisms of superoxide dismutases and catalase in diabetes mellitus.
Frey2006Changes in antioxidant defense enzymes after d-amphetamine exposure: implications as an animal model of mania.
Fujita2005Increased gene expression of antioxidant enzymes in KKAy diabetic mice but not in STZ diabetic mice.
Fujita2009Reduction of renal superoxide dismutase in progressive diabetic nephropathy.
Galbiati2011The anabolic/androgenic steroid nandrolone exacerbates gene expression modifications induced by mutant SOD1 in muscles of mice models of amyotrophic lateral sclerosis.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Gomes2007Antioxidant enzyme activities following acute or chronic methylphenidate treatment in young rats.
Gongora2006Role of extracellular superoxide dismutase in hypertension.
Hajiani2012Time- and dose-dependent differential regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase enzymatic activity and mRNA level by vitamin E in rat blood cells.
Han2007Anthocyanin-rich red potato flakes affect serum lipid peroxidation and hepatic SOD mRNA level in rats.
Hass1989"Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction."
Hayes-Punzo2012Gonadectomy and dehydroepiandrosterone (DHEA) do not modulate disease progression in the G93A mutant SOD1 rat model of amyotrophic lateral sclerosis.
Hinojos2005"Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes."
Ho1987cDNA and deduced amino acid sequence of rat copper-zinc-containing superoxide dismutase.
Hsu1992"Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison."
Hu2008Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels.
I+¦arrea2007"Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis."
Imamura2006"Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration."
Islinger2009Hitchhiking of Cu/Zn superoxide dismutase to peroxisomes--evidence for a natural piggyback import mechanism in mammals.
Ji2011"Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke."
Jin2006Identification of novel proteins associated with both alpha-synuclein and DJ-1.
Kadkhodaee2007Antioxidant vitamins preserve superoxide dismutase activities in gentamicin-induced nephrotoxicity.
Kedziora-Kornatowska2009Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients.
Keithley2005Cu/Zn superoxide dismutase and age-related hearing loss.
Khaper2003Antioxidant enzyme gene expression in congestive heart failure following myocardial infarction.
Kim2000Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat.
Kim1993Isolation and analysis of the rat genomic sequence encoding Cu/Zn superoxide dismutase.
Kobeissy2008Psychoproteomic analysis of rat cortex following acute methamphetamine exposure.
Kofler2005SOD1 overexpression and female sex exhibit region-specific neuroprotection after global cerebral ischemia due to cardiac arrest.
Lee2011Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Lee2007Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina.
Li2005A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis.
Lin2005Expression of superoxide dismutase in whole lens prevents cataract formation.
Llad+¦2005Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS.
Lobsiger2007Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.
Mahoney2006Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.
Malaspina2008Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression.
Mariappan2007TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol.
Miyara2008Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress.
Noriega2003Bilirubin is highly effective in preventing in vivo delta-aminolevulinic acid-induced oxidative cell damage.
Olofsson2009Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice.
Pajovi-ç2005Alterations in hippocampal antioxidant enzyme activities and sympatho-adrenomedullary system of rats in response to different stress models.
Panov2011Respiration and ROS production in brain and spinal cord mitochondria of transgenic rats with mutant G93a Cu/Zn-superoxide dismutase gene.
Pechenino2005Superoxide dismutase in the prostate lobes of aging Brown Norway rats.
Puga1987Isolation and nucleotide sequence of rat Cu/Zn superoxide dismutase cDNA clones.
Reeves2004Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet.
Rosen1993Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.
Sadi2007Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase.
Sahawneh2010"Cu,Zn-superoxide dismutase increases toxicity of mutant and zinc-deficient superoxide dismutase by enhancing protein stability."
Santillo2007Evidence of calcium- and SNARE-dependent release of CuZn superoxide dismutase from rat pituitary GH3 cells and synaptosomes in response to depolarization.
Sato2005Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.
Seshadri2012Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase.
Shimazu2004A peroxisome proliferator-activated receptor-gamma agonist reduces infarct size in transient but not in permanent ischemia.
Sinha2007Differential regulation of the superoxide dismutase family in experimental aortic aneurysms and rat aortic explants.
Son2007Chronic hypoxia aggravates renal injury via suppression of Cu/Zn-SOD: a proteomic analysis.
Song2012Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1+¦.
Sotelo-Silveira2009Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.
Sreekumar2002Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle.
Steffens1986The amino-acid sequence of rat Cu-Zn superoxide dismutase.
Stevens2010Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS).
Strassburger2005Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stroev2012"Threefold exposure to moderate hypobaric hypoxia decreases the expression of Cu,Zn-superoxide dismutase in some regions of rat hippocampus."
Suge2012Cerebral antioxidant enzyme increase associated with learning deficit in type 2 diabetes rats.
Tanaka2004Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts.
Tatton2002"Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells."
Taysi2002Serum oxidant/antioxidant status in patients with Beh+ºet's disease.
Thangaswamy2012Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.
Udar2006SOD1: a candidate gene for keratoconus.
van2006Age-associated cellular relocation of Sod 1 as a self-defense is a futile mechanism to prevent vascular aging.
Vesentini2012Selection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression.
Waelti2006Rapid endocytosis of copper-zinc superoxide dismutase into human endothelial cells: role for its vascular activity.
Wang1996Superoxide dismutase protects calcineurin from inactivation.
Webber2005Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat.
West2004"Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice."
White2010Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats.
Xiong2005Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase.
Xu2009Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation.
Yi2010The chronological characteristics of SOD1 activity and inflammatory response in the hippocampi of STZ-induced type 1 diabetic rats.
Yu2007Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
Yu2002Spatial and temporal correlation of nitric oxide synthase expression with CuZn-superoxide dismutase reduction in motor neurons following axotomy.
Zlatkovi-ç2011Stress-induced alternations in CuZnSOD and MnSOD activity in cellular compartments of rat liver.