GENE OVERVIEW OF ANIMAL MODEL


GeneOptn
Gene Nameoptineurin
Organism Namerat
Biological NameRattus norvegicus
Other NamesFip2
ChromosomeChr17 q12.3
Genomic coordinates 


BIOINFORMATICS

Entrez Gene   UCSC Browser      OMIM   KEGG   Full Literature        
 

ALL PUBLICATIONS (21)

First_AuthorYearTitle
Anborgh2005Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.
Chi2010Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
Del2011Novel optineurin mutations in patients with familial and sporadic amyotrophic lateral sclerosis.
Deng2011Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Hortob+ígyi2011Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders.
Jansson2005Analysis of rare variants and common haplotypes in the optineurin gene in Swedish glaucoma cases.
Koga2009"Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth."
Liu2008Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma.
Maruyama2010Mutations of optineurin in amyotrophic lateral sclerosis.
Melki2003The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma.
Moreland2000Identification of a transcription factor IIIA-interacting protein.
Mori2012"Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease."
Na2012Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Pruitt2000RefSeq and LocusLink: NCBI gene-centered resources.
Rezaie2002Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
Sahlender2005Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
Shen2010Processing of optineurin in neuronal cells.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Vittitow2002"Expression of optineurin, a glaucoma-linked gene, is influenced by elevated intraocular pressure."
Ying2010"Posttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma gene."