GENE OVERVIEW OF ANIMAL MODEL


GeneErbb4
Gene Namev-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Organism Namerat
Biological NameRattus norvegicus
Other Names 
ChromosomeChr9 q32
Genomic coordinates 


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ALL PUBLICATIONS (67)

First_AuthorYearTitle
Allison2011The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons.
Amsellem-Ouazana2006Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder.
Audisio2008ErbB receptors modulation in different types of peripheral nerve regeneration.
Barnes2005Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast.
Ben-Yosef2007Nuclear and cytoplasmic expression of ErbB-4 in prostate cancer.
Cant¾2006Neuregulins mediate calcium-induced glucose transport during muscle contraction.
Carroll1997Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration.
Chen2003Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
Clement2007Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells.
Darcy2000Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during growth, differentiation, and apoptosis of normal rat mammary epithelial cells.
Di2006ErbB4 activation inhibits MPP+-induced cell death in PC12-ErbB4 cells: involvement of PI3K and Erk signaling.
Di2005Neuregulins rescue PC12-ErbB-4 cells from cell death induced by beta-amyloid peptide: involvement of PI3K and PKC.
Dickerson2009Decreased expression of ErbB4 and tyrosine hydroxylase mRNA and protein in the ventral midbrain of aged rats.
Doggen2008Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure.
du2011Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life.
Dziedzic2003Neuron-to-glia signaling mediated by excitatory amino acid receptors regulates ErbB receptor function in astroglial cells of the neuroendocrine brain.
Ejskjaer2006Expression of the epidermal growth factor system in endometrioid endometrial cancer.
Feng2010Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration.
Fleisig2004Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase.
Fried2002Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.
Fuchs2007The prognostic significance of human epidermal growth factor receptor correlations in squamous cell cervical carcinoma.
Fukazawa2003Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt.
Gambarotta2004ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration.
Gui2008[Changes of ErbB receptors mRNA expression in left ventricle of myocardial infarction].
Higashiyama1997A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4.
Horie2010Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.
Icli2012ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
Junttila2003Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients.
Kalemi2007Expression of the HER family mRNA in breast cancer tissue and association with cell cycle inhibitors p21(waf1) and p27(kip1).
Kassouf2007Distinctive expression pattern of ErbB family receptors signifies an aggressive variant of bladder cancer.
Krivosheya2008ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms.
Kuai2011AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuramochi2004Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling.
Lacroix-Fralish2007Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: implications for sex specific pain modulation.
LaCroix-Fralish2007Sex differences in lumbar spinal cord gene expression following experimental lumbar radiculopathy.
Lai1991An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system.
Lai2004Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes.
Lebrasseur2003Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle.
Lezama2005Hyposmolarity-induced ErbB4 phosphorylation and its influence on the non-receptor tyrosine kinase network response in cultured cerebellar granule neurons.
Li2007The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.
Liu2009ErbB4 regulates surfactant synthesis and proliferation in adult rat pulmonary epithelial cells.
Liu2007Stimulated ErbB4 internalization is necessary for neuregulin signaling in neurons.
Liu2007The ErbB4 receptor in fetal rat lung fibroblasts and epithelial type II cells.
Longart2007Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons.
Ma2003Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.
Masuelli2007Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors.
Mechawar2007Developmental profile of neuregulin receptor ErbB4 in postnatal rat cerebral cortex and hippocampus.
Memon2006The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients.
Montero2008Neuregulins and cancer.
Pregno2011Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation.
Rohrbach1999Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors.
Rokavec2007A novel polymorphism in the promoter region of ERBB4 is associated with breast and colorectal cancer risk.
Sardi2006Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.
Sassen2008Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients.
Srinivasan1999Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer.
Steffensen2008Protein levels and gene expressions of the epidermal growth factor receptors, HER1, HER2, HER3 and HER4 in benign and malignant ovarian tumors.
Suo2001Phyllodes tumor of the breast: EGFR family expression and relation to clinicopathological features.
Tao2012Role of neuregulin-1/ErbB signaling in stem cell therapy for spinal cord injury-induced chronic neuropathic pain.
Thomasson2004ErbB4 is downregulated in renal cell carcinoma--a quantitative RT-PCR and immunohistochemical analysis of the epidermal growth factor receptor family.
Wang2008Chronic antipsychotic drug administration alters the expression of neuregulin 1beta, ErbB2, ErbB3, and ErbB4 in the rat prefrontal cortex and hippocampus.
Woo2007Neuregulin-1 enhances depolarization-induced GABA release.
Xu2005Upregulation of erbB receptors in rat brain after middle cerebral arterial occlusion.
Yau2003Neural development of the neuregulin receptor ErbB4 in the cerebral cortex and the hippocampus: preferential expression by interneurons tangentially migrating from the ganglionic eminences.
Zeng2007ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis.
Zhao1999Neuregulin signaling in the heart. Dynamic targeting of erbB4 to caveolar microdomains in cardiac myocytes.
Zhao1998Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes.
Zscheppang2007ErbB4 regulates fetal surfactant phospholipid synthesis in primary fetal rat type II cells.