GENE OVERVIEW OF ANIMAL MODEL


GeneVcp
Gene Namevalosin containing protein
Organism Namemouse
Biological NameMus musculus
Other NamesAAA ATPase p97|CDC48|p97|p97/VCP
ChromosomeChr4 22.95 cM
Genomic coordinates GRCm37Chr4:42979963-43000507 ( -)
Genomic coordinates GRCm38Chr4:42979963-43000507(-)


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ALL PUBLICATIONS (94)

First_AuthorYearTitle
Abaan2012Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.
Abisambra2013Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.
Alzayady2005"Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors."
Badadani2010VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease.
Barthelme2013Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase.
Behnam2005Identification and characterization of valosin-containing protein (VCP/p97) in untransformed osteoblast-like cells.
Beirowski2009WldS can delay Wallerian degeneration in mice when interaction with valosin-containing protein is weakened.
Boeddrich2006An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Bouwman2004Quantification of synapse formation and maintenance in vivo in the absence of synaptic release.
Boyault2007HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates.
Boyault2006HDAC6-p97/VCP controlled polyubiquitin chain turnover.
Briggs2008Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Cayli2009COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.
Chen2008The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.
Ching2012mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
Chou2011"Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways."
Custer2010"Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone."
Dai2001Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.
Davies2005Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering.
DeLaBarre2006Central pore residues mediate the p97/VCP activity required for ERAD.
Dreveny2004Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47.
Egerton1992"VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation."
Elkabetz2003Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.
Fujise2008"[p97ATPase-mediated biogenesis of the Golgi, ER and nuclear envelope]."
Griciuc2010Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCP.
Hansen2003"A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome."
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hatakeyama2004Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.
Hauler2012AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Hoyle1997"Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome."
Huang2012Dynamic flexibility of the ATPase p97 is important for its interprotomer motion transmission.
Huyton2003The crystal structure of murine p97/VCP at 3.6A.
Isaacson2007Detailed structural insights into the p97-Npl4-Ufd1 interface.
Ishigaki2004Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.
Jiang2013Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Ju2009Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
Kaneko2002Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kobayashi2002Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Koike2010Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.
Lagu+½2012Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers.
Laser2005"The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus."
Li2005"Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome."
Li2012Interprotomer motion-transmission mechanism for the hexameric AAA ATPase p97.
Li2006The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor.
Li2008Tyrosine phosphorylation of ATPase p97 regulates its activity during ERAD.
Liang2008Polycystin-2 is regulated by endoplasmic reticulum-associated degradation.
Lokireddy2012Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.
Lu2011"RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation."
M++ller1999"The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene."
M++ller2007Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality.
Mammen2011A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
Marutani2011"ER-stress-inducible Herp, facilitates the degradation of immature nicastrin."
Meyer2000"A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways."
Meyer2002"Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4."
Nagahama2003SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation.
Nakayasu2013Evaluation of selected binding domains for the analysis of ubiquitinated proteomes.
Nalbandian2012The homozygote VCP(R-¦ÔüÁÔüÁH/R-¦ÔüÁÔüÁH) mouse model exhibits accelerated human VCP-associated disease pathology.
Ohama2010Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Partridge2003DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP.
Piccirillo2012The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.
Pleasure1993"Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein."
Rao2003Molecular components of a cell death pathway activated by endoplasmic reticulum stress.
Rudra2012Transcription factor Foxp3 and its protein partners form a complex regulatory network.
Sansom2009The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Schulte1994"Tyrosine phosphorylation of VCP, the mammalian homologue of the Saccharomyces cerevisiae CDC48 protein, is unusually sensitive to stimulation by sodium vanadate and hydrogen peroxide."
Seigneurin-Berny2001Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Toonen2005"Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation."
Wang2011Valosin-containing protein and neurofibromin interact to regulate dendritic spine density.
Watahiki2005Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Weihl2005Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
Weihl2007Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Wertz2000Large-scale screen for genes involved in gonad development.
Wilbrey2008"VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S)."
Witke1998In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.
Ye2004A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.
Ye2001The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.
Yoshida2005Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zehner2011Mannose receptor polyubiquitination regulates endosomal recruitment of p97 and cytosolic antigen translocation for cross-presentation.
Zhang2001Structure of the AAA ATPase p97.
Zhao2009An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.
Zhao2007Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation.
Zhong2004"AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation."