GENE OVERVIEW OF ANIMAL MODEL


GeneUnc13a
Gene Nameunc-13 homolog A (C. elegans)
Organism Namemouse
Biological NameMus musculus
Other Names2410078G03Rik|Munc13-1
ChromosomeChr8 34.43 cM
Genomic coordinates GRCm37Chr8:71624417-71671757 ( -)
Genomic coordinates GRCm38Chr8:71624417-71671757(-)


BIOINFORMATICS

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ALL PUBLICATIONS (36)

First_AuthorYearTitle
Augustin1999Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.
Basu2007Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.
Burgalossi2010SNARE protein recycling by +¦SNAP and +¦SNAP supports synaptic vesicle priming.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Duncan1999"Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo."
Gerber2008Conformational switch of syntaxin-1 controls synaptic vesicle fusion.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Heupel2008Loss of transforming growth factor-beta 2 leads to impairment of central synapse function.
Hong2005SNAREs and traffic.
Kalla2006Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice.
Kang2006Munc13-1 is required for the sustained release of insulin from pancreatic beta cells.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kwan2007Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.
Kwan2006Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance.
Lou2008Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.
Mori2011Release of TNF-+¦ from macrophages is mediated by small GTPase Rab37.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Orenbuch2011Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.
Reimers2007Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.
Rhee2002Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.
Rosenmund2002Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.
Rossner2004Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.
Schoch2006Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Siksou2009A common molecular basis for membrane docking and functional priming of synaptic vesicles.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Tada2009"Fbxo45, a novel ubiquitin ligase, regulates synaptic activity."
Varoqueaux2005Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.
Varoqueaux2002Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.
Wang2009"A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1."
Xie2012Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.