GENE OVERVIEW OF ANIMAL MODEL


GeneTardbp
Gene NameTAR DNA binding protein
Organism Namemouse
Biological NameMus musculus
Other Names1190002A23Rik|TDP-43|Tdp43
ChromosomeChr4 78.77 cM
Genomic coordinates GRCm37Chr4:148612382-148627019 ( -)
Genomic coordinates GRCm38Chr4:148612382-148627019(-)


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ALL PUBLICATIONS (91)

First_AuthorYearTitle
Abhyankar2007A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.
Araki1999Exchangeable gene trap using the Cre/mutated lox system.
Arnold2013ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Avenda+¦o-V+ízquez2012"Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection."
Ayala2008Structural determinants of the cellular localization and shuttling of TDP-43.
Bailey2006A global genomic transcriptional code associated with CNS-expressed genes.
Berkovits2012The testis-specific double bromodomain-containing protein BRDT forms a complex with multiple spliceosome components and is required for mRNA splicing and 3'-UTR truncation in round spermatids.
Bonaldo1996Normalization and subtraction: two approaches to facilitate gene discovery.
Bose2011Regulation of autophagy by neuropathological protein TDP-43.
Bose2008TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing.
Buratti2007"Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease."
Campbell2011Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Cannon2012Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Chiang2010"Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism."
Cohen2011Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
Colombrita2012TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
Fallini2012The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth.
Fiesel2009Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6.
Friedel2007EUCOMM--the European conditional mouse mutagenesis program.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Hansen2003"A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome."
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hebron2012Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6).
Herskowitz2012Asparaginyl endopeptidase cleaves TDP-43 in brain.
Hideyama2012"Co-occurrence of TDP-43 mislocalization with reduced activity of an RNA editing enzyme, ADAR2, in aged mouse motor neurons."
Hong2012Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line.
Huang2010Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
Igaz2011Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
Iguchi2013Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Iguchi2009TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
Jeong2008Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawahara2012TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kim2008Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia.
Kleinberger2010Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures.
Ko2000Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Kraemer2010Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Lagier-Tourenne2012Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Lalmansingh2011TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.
Leggett2012Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Majumder2012TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1.
McKee2005A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
McMahon2008GUDMAP: the genitourinary developmental molecular anatomy project.
Moisse2009Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury.
Moisse2008Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Pelletier2012An early onset progressive motor neuron disorder in Scyl1-deficient mice is associated with mislocalization of TDP-43.
Piao2001Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piazzi2013Phosphoinositide-specific phospholipase C +¦ 1b (PI-PLC+¦1b) interactome: affinity purification-mass spectrometry analysis of PI-PLC+¦1b with nuclear protein.
Polymenidou2011Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Prudencio2012Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor.
Ravasi2010An atlas of combinatorial transcriptional regulation in mouse and man.
Rodriguez-Ortiz2013Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Sato2009Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Schebelle2010Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.
Scofield2012"Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis."
Sephton2009TDP-43 is a developmentally regulated protein essential for early embryonic development.
Shan2010Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Sharma2010CSP+¦ promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Suzuki2011TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
Suzuki2012The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death.
Swarup2011Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor +¦B-mediated pathogenic pathways.
Tamplin2008Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Taniwaki2005Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Tauffenberger2012"Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models."
Tsai2010Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Tsao2012Rodent models of TDP-43: recent advances.
Tudor2010Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
Turner2008TDP-43 expression in mouse models of amyotrophic lateral sclerosis and spinal muscular atrophy.
van2011Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
Wang2012Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
Wang2002Higher order arrangement of the eukaryotic nuclear bodies.
Wang2003Structural diversity and functional implications of the eukaryotic TDP gene family.
Watahiki2005Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Wils2012"Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice."
Winton2008"Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation."
Wu2009"TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis."
Wu2012Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.
Yokoyama2010A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zheng2012Regulation of nuclear TDP-43 by NR2A-containing NMDA receptors and PTEN.