GENE OVERVIEW OF ANIMAL MODEL


GeneSqstm1
Gene Namesequestosome 1
Organism Namemouse
Biological NameMus musculus
Other NamesA170|OSF-6|Osi|p62|STAP
ChromosomeChr11 30.36 cM
Genomic coordinates GRCm37Chr11:50199366-50210827 ( -)
Genomic coordinates GRCm38Chr11:50199366-50210827(-)


BIOINFORMATICS

Entrez Gene   UCSC Browser      OMIM   KEGG   Full Literature        
 

ALL PUBLICATIONS (116)

First_AuthorYearTitle
Abdulrahman2012Depletion of the ubiquitin-binding adaptor molecule SQSTM1/p62 from macrophages harboring cftr +öF508 mutation improves the delivery of Burkholderia cenocepacia to the autophagic machinery.
Ang2009"Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades."
Aono2003Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts.
Bae2013Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Ballif2004Phosphoproteomic analysis of the developing mouse brain.
Barrios-Rodiles2005High-throughput mapping of a dynamic signaling network in mammalian cells.
Bj+©rk+©y2005p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Castillo2012Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.
Copple2010Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway.
Daroszewska2011A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Doi2013p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.
Du2008Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease.
Dur+ín2004The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.
Duran2011p62 is a key regulator of nutrient sensing in the mTORC1 pathway.
Duran2008The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.
Fan2010Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
Fujita2011Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation.
Fusco2012"The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome."
Gal2007p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis.
Gal2009Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
Geetha2012"Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein."
Geetha2005"TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor."
Geetha2008p62 serves as a shuttling factor for TrkA interaction with the proteasome.
Geetha2002Structure and functional properties of the ubiquitin binding protein p62.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Grasso2010"Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death."
Gray2004Mouse brain organization revealed through direct genome-scale TF expression analysis.
Guo2011Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
Hiruma2008A SQSTM1/p62 mutation linked to Paget's disease increases the osteoclastogenic potential of the bone microenvironment.
Hiruma2009Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation.
Holtz2005Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death.
Huang2011Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.
Ichimura2008Structural basis for sorting mechanism of p62 in selective autophagy.
Inami2011Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
Ishii1997Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages.
Ishii1996Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress.
Isogai2011Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin.
Itakura2011p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding.
Jain2010p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.
Jiang2008AMPA receptor trafficking and synaptic plasticity require SQSTM1/p62.
Jin2008Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kim2008D2 dopamine receptor expression and trafficking is regulated through direct interactions with ZIP.
Kim2009The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity.
Kirkin2009A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Komatsu2007Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu2010The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Kuo2011Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity.
Kurihara2011Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.
Kuusisto2001Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells.
Kwon2012Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Laurin2002Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.
Lee2010A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis.
Lee2011Autophagy suppresses interleukin-1+¦ (IL-1+¦) signaling by activation of p62 degradation via lysosomal and proteasomal pathways.
Lee1999Gene expression profile of aging and its retardation by caloric restriction.
Lee2011Triage of oxidation-prone proteins by Sqstm1/p62 within the mitochondria.
Li2010A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Li2013Loss of acinar cell IKK+¦ triggers spontaneous pancreatitis in mice.
Liang2013p62 sequestosome 1/light chain 3b complex confers cytoprotection on lung epithelial cells after hyperoxia.
Linares2010Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation.
Liu2010FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.
Lock2010Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation.
M++ller2012p62 links +¦-adrenergic input to mitochondrial function and thermogenesis.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Mari+¦o2010Autophagy is essential for mouse sense of balance.
Martin2006The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation.
McMahon2008GUDMAP: the genitourinary developmental molecular anatomy project.
Meenhuis2011MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice.
Myeku2011Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
Nagaoka2004Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.
Narendra2010p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both.
Okatsu2010p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Okazaki1999"Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene."
Pan2011Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes.
Papin2004Bioinformatics and cellular signaling.
Parkhitko2011Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent.
Paul2012Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-+¦B.
Peng2012Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes.
Perera2010"Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover."
Piao2001Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Ponpuak2010Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties.
Ramesh2008Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.
Rea2009"Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding."
Riley2010Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
Rivera2010Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic +¦-cells: protective role of p62-positive cytoplasmic inclusions.
Rodriguez2006Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
Ru+®2013Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Sundaram2011Mutant p62P392L stimulation of osteoclast differentiation in Paget's disease of bone.
Tabuchi2009Cochlear protection from acoustic injury by inhibitors of p38 mitogen-activated protein kinase and sequestosome 1 stress protein.
Takamura2011Autophagy-deficient mice develop multiple liver tumors.
Takamura2011Lysosomal accumulation of Trk protein in brain of GMÔéü -gangliosidosis mouse and its restoration by chemical chaperone.
Tanabe2011Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: functional analysis of p62 and autophagy in hypoxic neuronal cells.
Traver2011Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
Ullman2011Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury.
Wang2013FIP200 is required for maintenance and differentiation of postnatal neural stem cells.
Weinert2006M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.
Whitehouse2010Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Wiese2012A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Williams2012Tissue specific induction of p62/Sqstm1 by farnesoid X receptor.
Wooten2008Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins.
Yanagawa1998Phosphorylation of A170 stress protein by casein kinase II-like activity in macrophages.
Yip2006p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone.
Yokoyama2010A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yu2009Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zhang2011Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Zhou2007Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.