GENE OVERVIEW OF ANIMAL MODEL


GeneSpast
Gene Namespastin
Organism Namemouse
Biological NameMus musculus
Other NamesmKIAA1083|Spg4
ChromosomeChr17 45.64 cM
Genomic coordinates GRCm37Chr17:74338987-74391113 ( +)
Genomic coordinates GRCm38Chr17:74338987-74391113(+)


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ALL PUBLICATIONS (32)

First_AuthorYearTitle
Canbaz2011SPG4 gene promoter regulation via Elk1 transcription factor.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Charvin2002"Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus."
Claudiani2005Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus.
Errico2004"Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon."
Fassier2012Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.
Fink2004Hereditary spastic paraplegia: spastin phenotype and function.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Hansen2003"A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome."
Hazan1999"Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia."
Kasher2009Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Lacroix2010Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Murmu2011"Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia."
Nielsen2005Hereditary spastic paraplegia with cerebellar ataxia: a complex phenotype associated with a new SPG4 gene mutation.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Okazaki2003Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Quwailid2004A gene-driven ENU-based approach to generating an allelic series in any gene.
Riano2009Pleiotropic effects of spastin on neurite growth depending on expression levels.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Tarrade2006A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.
Visel2003GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Yu2008The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.