Gene Namesuperoxide dismutase 1, soluble
Organism Namemouse
Biological NameMus musculus
Other NamesB430204E11Rik|Cu(2+)-Zn2+ superoxide dismutase|Cu/Zn-SOD|CuZnSOD|Ipo-1|Ipo1|Sod-1|SODC
ChromosomeChr16 51.56 cM
Genomic coordinates GRCm37Chr16:90220742-90226322 ( +)
Genomic coordinates GRCm38Chr16:90220742-90226322(+)


Entrez Gene   UCSC Browser      OMIM   KEGG   Full Literature        


Select Title
Abdelmegeed2009Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity.
Akhtar2013Sod1 deficiency reduces incubation time in mouse models of prion disease.
Alexianu2001Immune reactivity in a mouse model of familial ALS correlates with disease progression.
Almer1999Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Andreassen2001"Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice."
Andreassen2001Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.
Andreassen2000Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis.
Aoyama2012Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.
Arciello2010Copper depletion increases the mitochondrial-associated SOD1 in neuronal cells.
Asimakis2002Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts.
Atkin2006Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.
Audet2010Wild-type human SOD1 overexpression does not accelerate motor neuron disease in mice expressing murine Sod1 G86R.
Avossa2006Early signs of motoneuron vulnerability in a disease model system: Characterization of transverse slice cultures of spinal cord isolated from embryonic ALS mice.
Azari2001Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis.
Bandyopadhyay2013RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.
Banerjee2008Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
Banks2009Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
Bannister1991Evolutionary aspects of superoxide dismutase: the copper/zinc enzyme.
Bar-Peled1996Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.
Barati2007Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice.
Barlow1991The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus.
Barn+®oud1999"Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis."
Bartnikas2003Mechanisms of biosynthesis of mammalian copper/zinc superoxide dismutase.
Bassett1997Genome cross-referencing and XREFdb: implications for the identification and analysis of genes mutated in human disease.
Basso2009Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.
Basso2013Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes: implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis.
Baumbach2006Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase.
Baumgart2001Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse).
Bechara2009A novel function for fragile X mental retardation protein in translational activation.
Behndig2008Corneal endothelial integrity in aging mice lacking superoxide dismutase-1 and/or superoxide dismutase-3.
Behndig2001In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase.
Bendotti2001Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels.
Benedetto1991Isolation and analysis of the mouse genomic sequence encoding Cu(2+)-Zn2+ superoxide dismutase.
Benedusi2012The peroxisome proliferator-activated receptor +¦ (PPAR+¦) controls natural protective mechanisms against lipid peroxidation in amyotrophic lateral sclerosis.
Bewley1988cDNA and deduced amino acid sequence of murine Cu-Zn superoxide dismutase.
Bhattacharya2008Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria.
Bhusari2010Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate.
Bloor1983Characterization of superoxide dismutase (SOD-1 and SOD-2) activities in inbred mice: evidence for quantitative variability and possible nonallelic SOD-1 polymorphism.
Bonhomme1984Biochemical diversity and evolution in the genus Mus.
Bordet2001Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice.
Boston-Howes2006Caspase-3 cleaves and inactivates the glutamate transporter EAAT2.
Brich2003Genetic modulation of tau phosphorylation in the mouse.
Broad1995Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q.
Brookes1992"Localization of four human chromosome 21 genes--SOD1, ETS2, IFNAR, and CBR--to two different chromosomes in the marsupial species Macropus eugenii."
Brown1995Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice.
Bruijn1998Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.
Bryson2012Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Brz+¦ska2011Alterations in the expression of genes related to NF-+¦B signaling in liver and kidney of CuZnSOD-deficient mice.
Busuttil2005Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice.
Carlson1997Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.
Carlstr+Âm2009SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Carrasco2010Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
Carroll2004Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone.
Cha2000Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.
Chang-Hong2005Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis.
Cheng1988Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.
Chiu2009Yam (Dioscorea pseudojaponica Yamamoto) ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.
Choung2004Extracellular superoxide dismutase tissue distribution and the patterns of superoxide dismutase mRNA expression following ultraviolet irradiation on mouse skin.
Chung2009Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death.
Chung2004Enhanced expression of erythropoietin in the central nervous system of SOD1(G93A) transgenic mice.
Chung2008Immunohistochemical study on the distribution of glycogen synthase kinase 3alpha in the central nervous system of SOD1(G93A) transgenic mice.
Chung2005Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice.
Clarke2006Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.
Coling2003Effect of SOD1 overexpression on age- and noise-related hearing loss.
Comim2009Oxidative variables and antioxidant enzymes activities in the mdx mouse brain.
Cooke2003Endothelial-dependent vasodilation is reduced in mesenteric arteries from superoxide dismutase knockout mice.
Copin2000Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase.
Couillard-Despr+®s2000"Extra axonal neurofilaments do not exacerbate disease caused by mutant Cu,Zn superoxide dismutase."
Couillard-Despr+®s1998Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase.
Cox1985Comparative gene mapping of human chromosome 21 and mouse chromosome 16.
Cox1980Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16.
Cozzolino2009Oligomerization of mutant SOD1 in mitochondria of motoneuronal cells drives mitochondrial damage and cell toxicity.
Crochemore2005Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Cummings2007Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing.
Dal1997"A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis."
Dasgupta2009Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.
Davisson1993Segmental trisomy as a mouse model for Down syndrome.
de1992"Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains."
de1994"Expression of copper/zinc superoxide dismutase and glutathione peroxidase in organs of developing mouse embryos, fetuses, and neonates."
de1996Equine motor neuron disease is not linked to Cu/Zn superoxide dismutase mutations: sequence analysis of the equine Cu/Zn superoxide dismutase cDNA.
Deitch2002GLT-1 glutamate transporter levels are unchanged in mice expressing G93A human mutant SOD1.
DeRubertis2007Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol.
Dewil2007Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death.
Diaz2005Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency.
Didion2005Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunction.
Didion2006Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging.
Didion2002Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Dobrowolny2008Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.
Dohlen2007Antioxidant activity in the newborn brain: a luciferase mouse model.
Dong2006Superoxide dismutase 1 protects retinal cells from oxidative damage.
Dong2011Vascular cell-adhesion molecule-1 plays a central role in the proangiogenic effects of oxidative stress.
Dupuis2000Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons.
El1999Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation.
El-Kadi2010The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.
Elchuri2004CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Elchuri2007Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice.
Elliott2001Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis.
Elliott1999Experimental models of amyotrophic lateral sclerosis.
Epstein1987Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.
Erker2006Effect of the reduction of superoxide dismutase 1 and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice.
Ezzi2007Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation.
Faraci2004Vascular protection: superoxide dismutase isoforms in the vessel wall.
Farr2011Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice.
Ferraiuolo2011Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis.
Ferrante1997Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.
Ferri2010Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.
Ferri2008Inflammatory cytokines increase mitochondrial damage in motoneuronal cells expressing mutant SOD1.
Ferrucci2008Pathways of methamphetamine toxicity.
Figlewicz1994Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.
Filipchuk2012Postnatal dendritic development in lumbar motoneurons in mutant superoxide dismutase 1 mouse model of amyotrophic lateral sclerosis.
Fischer2011Absence of SOD1 leads to oxidative stress in peripheral nerve and causes a progressive distal motor axonopathy.
Fischer2010SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse.
Fishman2009Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD.
Flood1999Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions.
Forejt1991Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene.
Francke1979Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse.
Francke1982Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21.
Franke2004Enhanced plasminogen activator inhibitor-1 expression in transgenic mice with hepatocyte-specific overexpression of superoxide dismutase or glutathione peroxidase.
Fray2001Glutamine synthetase activity and expression are not affected by the development of motor neuronopathy in the G93A SOD-1/ALS mouse.
Fujimura2001"Reduction of copper, zinc-superoxide dismutase in knockout mice does not affect edema or infarction volumes and the early release of mitochondrial cytochrome c after permanent focal cerebral ischemia."
Fujita2012"SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice."
Fujita2005Increased gene expression of antioxidant enzymes in KKAy diabetic mice but not in STZ diabetic mice.
Fujita2009Reduction of renal superoxide dismutase in progressive diabetic nephropathy.
Fujiwara2007Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.
Fukada2002Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice.
Fukuhara2002"Structure, molecular evolution, and gene expression of primate superoxide dismutases."
Furukawa2006"Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice."
Gal2013HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation.
Gal2007p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis.
Gal2009Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.
Garbuzova-Davis2006Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis.
Gerber2012"Unlike physical exercise, modified environment increases the lifespan of SOD1G93A mice however both conditions induce cellular changes."
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Ghadge1997Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection.
Ghoshal1999"Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice."
Giess2002Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene.
Gitton2002A gene expression map of human chromosome 21 orthologues in the mouse.
Glozman2000Docosahexaenoic acid-deficient phosphatidyl serine and high alpha-tocopherol in a fetal mouse brain over-expressing Cu/Zn-superoxide dismutase.
Goldsteins2008Deleterious role of superoxide dismutase in the mitochondrial intermembrane space.
Gonz+ílez2000Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway.
Gowing2008Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.
Grad2011Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.
Green1999Animal models for motor neuron disease.
Greenough2011Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
Gregor1993Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Groleau2011Accelerated vascular aging in CuZnSOD-deficient mice: impact on EPC function and reparative neovascularization.
Groleau2010Essential role of copper-zinc superoxide dismutase for ischemia-induced neovascularization via modulation of bone marrow-derived endothelial progenitor cells.
Grzelak2008The effects of superoxide dismutase knockout on the oxidative stress parameters and survival of mouse erythrocytes.
Gu1995"In male mouse germ cells, copper-zinc superoxide dismutase utilizes alternative promoters that produce multiple transcripts with different translation potential."
Gu1996Translation of a testis-specific Cu/Zn superoxide dismutase (SOD-1) mRNA is regulated by a 65-kilodalton protein which binds to its 5' untranslated region.
Gu+®gan2001Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis.
Guo2000ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury.
Gurney1994"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation."
Hadano2010Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
Hadjur2001Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase.
Hafezparast2003Mutations in dynein link motor neuron degeneration to defects in retrograde transport.
Hamatani2004Age-associated alteration of gene expression patterns in mouse oocytes.
Han2008The in vivo gene expression signature of oxidative stress.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Harraz2008SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.
Harvey1995Expression of genes encoding antioxidant enzymes in preimplantation mouse and cow embryos and primary bovine oviduct cultures employed for embryo coculture.
Hashizume2008Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice.
He2013"Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages."
Hegedus2008Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis.
Henriques2010Characterization of a novel SOD-1(G93A) transgenic mouse line with very decelerated disease development.
Herron2012Gender-specific perturbations in modulatory inputs to motoneurons in a mouse model of amyotrophic lateral sclerosis.
Hilkens1986Genetic mapping of Pim-1 putative oncogene to mouse chromosome 17.
Hilkens1983Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16.
Ho1998Reduced fertility in female mice lacking copper-zinc superoxide dismutase.
Ho1998The nature of antioxidant defense mechanisms: a lesson from transgenic studies.
Hoffman1996Proteasome inhibition enhances the stability of mouse Cu/Zn superoxide dismutase with mutations linked to familial amyotrophic lateral sclerosis.
Hottinger1997The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Hoyaux2000"S100A6, a calcium- and zinc-binding protein, is overexpressed in SOD1 mutant mice, a model for amyotrophic lateral sclerosis."
Huang1997Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts.
Huang2000Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
Hwang2010Nonamyloid aggregates arising from mature copper/zinc superoxide dismutases resemble those observed in amyotrophic lateral sclerosis.
Igarashi2001"Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase."
Iida2002"M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene."
Ikeda1995Lecithinized superoxide dismutase retards wobbler mouse motoneuron disease.
Ilieva2002Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice.
Ilieva2008Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death.
Imam2001Peroxynitrite plays a role in methamphetamine-induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or overexpressing copper-zinc superoxide dismutase.
Imamura2006"Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration."
Irving1991Mouse chromosome-specific markers generated by PCR and their mapping through interspecific backcrosses.
Irving1989The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6.
Irving1991The multipoint genetic mapping of mouse chromosome 16.
Irving1993The positions of 12 simple sequence repeat markers relative to reference loci on mouse chromosome 16.
Ishigami2011Deficiency of CuZn superoxide dismutase promotes inflammation and alters medial structure following vascular injury.
Ishii2005Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress.
Israelson2010Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS.
Issa2006MusTRD can regulate postnatal fiber-specific expression.
Iuchi2008"Deficiency of the cystine-transporter gene, xCT, does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice."
Iuchi2006Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production.
Iuchi2010Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice.
Iuchi2009Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes.
Iuchi2010Spontaneous skin damage and delayed wound healing in SOD1-deficient mice.
Jaarsma2000"Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1."
Jaarsma2008Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.
Jackson2006"Lack of CuZnSOD activity: a pointer to the mechanisms underlying age-related loss of muscle function, a commentary on absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy""."""
Jang2011Cu/Zn superoxide dismutase is differentially regulated in period gene-mutant mice.
Jang2009Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.
Jayanthi1999Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy).
Jiang2000Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice.
Jiang2001The effects of aging on gene expression in the hypothalamus and cortex of mice.
Johnson2005Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes.
Johnson2010Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice.
Jokic2004Early activation of antioxidant mechanisms in muscle of mutant Cu/Zn-superoxide dismutase-linked amyotrophic lateral sclerosis mice.
Jones2002Role of intracellular antioxidant enzymes after in vivo myocardial ischemia and reperfusion.
Jones1997Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta and NF-kappaB.
Jonsson2006Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1.
Joosten2001Cellular changes in motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis as revealed by monoclonal antibody Py.
Julien2000Cytoskeletal abnormalities in amyotrophic lateral sclerosis: beneficial or detrimental effects?
Julien1998Transgenic mice in the study of ALS: the role of neurofilaments.
Jun2009Extracellular superoxide dismutase polymorphism in mice: Allele-specific effects on phenotype.
Kamsler2006Aged SOD overexpressing mice exhibit enhanced spatial memory while lacking hippocampal neurogenesis.
Kamsler2003Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice.
Kanekura2004"A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death."
Karanjawala2003Overexpression of Cu/Zn superoxide dismutase is lethal for mice lacking double-strand break repair.
Karch2008A limited role for disulfide cross-linking in the aggregation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.
Karch2010Aggregation modulating elements in mutant human superoxide dismutase 1.
Karch2010An examination of alpha B-crystallin as a modifier of SOD1 aggregate pathology and toxicity in models of familial amyotrophic lateral sclerosis.
Karch2009Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.
Kariya2012"Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies."
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kawamata2008Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria.
Kawase1999Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency.
Keithley2005Cu/Zn superoxide dismutase and age-related hearing loss.
Keller2010Treatment with minocycline after disease onset alters astrocyte reactivity and increases microgliosis in SOD1 mutant mice.
Kessova2003"Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase."
Kessova2007Mitochondrial alterations in livers of Sod1-/- mice fed alcohol.
Khan2003Developmental changes in murine brain antioxidant enzymes.
Kikuchi2006Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model.
Kim2009Accumulation of labile zinc in neurons and astrocytes in the spinal cords of G93A SOD-1 transgenic mice.
Kim2013Characterization and Hsp104-induced artificial clearance of familial ALS-related SOD1 aggregates.
Kim2011Effect of CCS on the accumulation of FALS SOD1 mutant-containing aggregates and on mitochondrial translocation of SOD1 mutants: implication of a free radical hypothesis.
Kim2003Neurodegeneration in striatum induced by the mitochondrial toxin 3-nitropropionic acid: role of matrix metalloproteinase-9 in early blood-brain barrier disruption?
Kim2006Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim2005Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants.
Klivenyi1999Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.
Kofler2005SOD1 overexpression and female sex exhibit region-specific neuroprotection after global cerebral ischemia due to cardiac arrest.
Kong1999Peripheral axotomy slows motoneuron degeneration in a transgenic mouse line expressing mutant SOD1 G93A.
Kostrominova2010Advanced age-related denervation and fiber-type grouping in skeletal muscle of SOD1 knockout mice.
Kozak1980Genetic mapping of the ecotropic virus-inducing locus Akv-2 of the AKR mouse.
Kruman2000ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis.
Kubodera2010In vivo application of an RNAi strategy for the selective suppression of a mutant allele.
Kubota2010Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
Kuo2005Increased persistent Na(+) current and its effect on excitability in motoneurones cultured from mutant SOD1 mice.
Kurahashi2012A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice.
Lange2005Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies.
Larkin2011Skeletal muscle weakness due to deficiency of CuZn-superoxide dismutase is associated with loss of functional innervation.
Le2005Oxidized SOD1 alters proteasome activities in vitro and in the cortex of SOD1 overexpressing mice.
Lee2009Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells.
Lee2009Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice.
Lee2011Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.
Lee2013MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.
Lei2006"Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity."
Leichsenring2006Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.
Lelie2010Copper and zinc metallation status of copper-zinc superoxide dismutase from amyotrophic lateral sclerosis transgenic mice.
Lenzen1996Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.
Lev2008DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS.
Levkovitz1999Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice.
Levy2001Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia.
Li2011Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity.
Li1998Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR.
Li1998Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: mechanistic studies.
Li2004Overexpressed mutant G93A superoxide dismutase protects calcineurin from inactivation.
Li2006Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.
Li2011SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy.
Ligon2005Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons.
Lin1980Assignment of the murine interferon sensitivity and cytoplasmic superoxide dismutase genes to chromosome 16.
Lin2005RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration.
Lincecum2010From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis.
Liu1999"The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids."
Liu2008Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2.
Liu2011Genetic analysis of Down syndrome-associated heart defects in mice.
Liu2002Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival.
Liu2004Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.
Lobsiger2009Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice.
Lobsiger2007Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons.
Lokireddy2012Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.
Lu2009Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor.
Lu2012Plasma neurofilament heavy chain levels correlate to markers of late stage disease progression and treatment response in SOD1(G93A) mice that model ALS.
Luche1997Novel mutations in an otherwise strictly conserved domain of CuZn superoxide dismutase.
Lungato2013Sleep deprivation alters gene expression and antioxidant enzyme activity in mice splenocytes.
M+®rad-Sa+»doune1999Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion.
Machka2005Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.
Madamanchi2005Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Maggi2008Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Mahoney2006Oxidative stress and antioxidant enzyme upregulation in SOD1-G93A mouse skeletal muscle.
Maka+éowski1996Comparative analysis of 1196 orthologous mouse and human full-length mRNA and protein sequences.
Mali2009VEGF up-regulation by G93A superoxide dismutase and the role of malate-aspartate shuttle inhibition.
Manabe2001Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene.
Mancuso2012Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis.
Martin2009The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice.
Massilamany2013Copper-zinc superoxide dismutase-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein 35-55.
Mathews1999Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice.
Matzuk1998Ovarian function in superoxide dismutase 1 and 2 knockout mice.
Mayra2011Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles.
McFadden1999"Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice."
McFadden1999Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase.
Meehan2010Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents.
Meissner2010Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.
Meissner2008Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.
Mirochnitchenko1995Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases.
Mishra2012E6-AP association promotes SOD1 aggresomes degradation and suppresses toxicity.
Mittag2000Light-induced retinal damage in mice carrying a mutated SOD I gene.
Mjaatvedt1993"High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16."
Mootha2003"Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria."
Morikawa2003"Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization."
Morrison1999Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration.
Morrison2000Early and selective pathology of light chain neurofilament in the spinal cord and sciatic nerve of G86R mutant superoxide dismutase transgenic mice.
Morrison1996Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability.
Muller2006Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.
Muller2004Complex III releases superoxide to both sides of the inner mitochondrial membrane.
Muller2007Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.
Muller2007Trends in oxidative aging theories.
Murakami1997Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice.
Murakami2009Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.
Murakami2011SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid +¦ protein oligomerization and memory loss in mouse model of Alzheimer disease.
Mysore2005Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function.
Nakatani1997Overexpression of antioxidant enzymes in transgenic mice decreases cellular ploidy during liver regeneration.
Nguyen2001Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions.
Nguyen2012Morphological and functional changes in innervation of a fast forelimb muscle in SOD1-G85R mice.
Nguyen2009The Psi(m) depolarization that accompanies mitochondrial Ca2+ uptake is greater in mutant SOD1 than in wild-type mouse motor terminals.
Nimchinsky1999"Differential vulnerability of oculomotor, facial, and hypoglossal nuclei in G86R superoxide dismutase transgenic mice."
Nishitoh2008ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Niwa2007"Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1."
Noda2011Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice.
Noh2011Hepatoprotective effects of chestnut (Castanea crenata) inner shell extract against chronic ethanol-induced oxidative stress in C57BL/6 mice.
Noshita2002Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice.
O'Brien1982Genetic mapping in mammals: chromosome map of domestic cat.
O'Hara1988Genetic mapping and analysis of somatostatin expression in Snell dwarf mice.
Oberley1978"Superoxide dismutase activity of normal murine liver, regenerating liver, and H6 hepatoma."
Offen2008Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant.
Ohlemiller1999Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss.
Okado-Matsumoto2002Amyotrophic lateral sclerosis: a proposed mechanism.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Olofsson2009Enhanced diabetes-induced cataract in copper-zinc superoxide dismutase-null mice.
Olofsson2007Glucose-induced cataract in CuZn-SOD null lenses: an effect of nitric oxide?
Orelio2002Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.
Pagliarini2008A mitochondrial protein compendium elucidates complex I disease biology.
Pang2010Regulation of fasting fuel metabolism by toll-like receptor 4.
Papaioannou2010Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice.
Parone2013Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis.
Pasinelli2004Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.
Pedersen2000The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis.
Pedrini2010ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
Peter2001Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.
Piao2001Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Pluthero1990Purification of an inhibitor of erythroid progenitor cell cycling and antagonist to interleukin 3 from mouse marrow cell supernatants and its identification as cytosolic superoxide dismutase.
Pramatarova2001Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.
Proescher2008Biological effects of CCS in the absence of SOD1 enzyme activation: implications for disease in a mouse model for ALS.
Prohaska2003"Copper, zinc-superoxide dismutase protein but not mRNA is lower in copper-deficient mice and mice lacking the copper chaperone for superoxide dismutase."
Prudlo2000Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.
Puttaparthi2003Aggregate formation in the spinal cord of mutant SOD1 transgenic mice is reversible and mediated by proteasomes.
Rakhit2006"Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis."
Ramiro-Diaz2013NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice.
Raoul2006"Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL."
Raoul2005Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.
Ratty1992"Genetic mapping of two DNA markers, D16Ros1 and D16Ros2, flanking the mutation site in the chakragati mouse, a transgenic insertional mutant."
Reaume1996Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Rebelo2007DRG11 immunohistochemical expression during embryonic development in the mouse.
Reddy2005Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium.
Reeves1987"Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16."
Reeves1990"Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16."
Reeves1995A mouse model for Down syndrome exhibits learning and behaviour deficits.
Reeves1987Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man.
Reeves1988Genetic mapping of the Mx influenza virus resistance gene within the region of mouse chromosome 16 that is homologous to human chromosome 21.
Reeves1997High-resolution recombinational map of mouse chromosome 16.
Reeves1989The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21.
Reinholz1999Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Reymond2002Human chromosome 21 gene expression atlas in the mouse.
Ripps1995Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis.
Robert2003Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain.
Roberts2013Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype.
Rosen1993Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.
Rutten2010Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice.
S+ínchez-Carbente2005Motoneuronal death during spinal cord development is mediated by oxidative stress.
Saito2005Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
Saito2006Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mouse brains after transient focal cerebral ischemia.
Saito2005Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model.
Sakellariou2011"Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase."
Sang2011Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Sarco2000The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain.
Sasaki2009Mitochondrial alterations in transgenic mice with an H46R mutant Cu/Zn superoxide dismutase gene.
Sasaki2010PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Sch+ñfer1980Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids.
Schibler1998Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans.
Schmidt-Ott2006c-kit delineates a distinct domain of progenitors in the developing kidney.
Schnabel2006Expression and regulation of antioxidant enzymes in the developing limb support a function of ROS in interdigital cell death.
Schuessel2005Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice.
Seetharaman2010Structures of mouse SOD1 and human/mouse SOD1 chimeras.
Sentman2005Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase.
Shan2012Reduced protein O-glycosylation in the nervous system of the mutant SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
Shaw2008"Detergent-insoluble aggregates associated with amyotrophic lateral sclerosis in transgenic mice contain primarily full-length, unmodified superoxide dismutase-1."
Shefner1999Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy.
Sheldon2002Copper/zinc superoxide dismutase transgenic brain in neonatal hypoxia-ischemia.
Shi2010Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shimazawa2010An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
Shin2005Proteome analysis in hippocampus of mice overexpressing human Cu/Zn-superoxide dismutase 1.
Siegel2011Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Smietana2010"Reactive oxygen species on bone mineral density and mechanics in Cu,Zn superoxide dismutase (Sod1) knockout mice."
Smittkamp2007Time-course and characterization of orolingual motor deficits in B6SJL-Tg(SOD1-G93A)1Gur/J mice.
Son2007Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology.
Son2009Redox susceptibility of SOD1 mutants is associated with the differential response to CCS over-expression in vivo.
Song2008"Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes."
Soo2008Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.
Soon2011Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model.
Sozmen2008Cyclin A expression is associated with apoptosis and mitosis in murine 3-methylcholanthrene-induced fibrosarcomas.
Spalloni2010"Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alphaCaMKII at threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1G93A mice, a murine model for amyotrophic lateral sclerosis."
Staats2012"Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(GÔü¦-¦A) mice."
Starzy+äski2009"Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase."
Starzynski2004Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism.
Strassburger2005Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Subramaniam2002Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading.
Tabuchi2011Age-related hearing loss and expression of antioxidant enzymes in BDF1 mice.
Taes2013Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Taira2007"Dose-dependent effects of Ni (II) ions on production of three inflammatory cytokines (TNF-alpha, IL-1beta and IL-6), superoxide dismutase (SOD) and free radical NO by murine macrophage-like RAW264 cells with or without LPS-stimulation."
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Tankersley2006Respiratory impairment in a mouse model of amyotrophic lateral sclerosis.
Taylor2004"Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity."
Taylor1995"Typing recombinant inbred mouse strains for microsatellite markers on chromosomes 10, 16, 18, 19, and X."
Thiruchelvam2005Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype.
Threadgill1991Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.
Tkatchenko2001Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia.
Towne2008Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice.
Tripanichkul200717Beta-estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult.
Tsunoda2012Impaired fertilizing ability of superoxide dismutase 1-deficient mouse sperm during in vitro fertilization.
Turner2005Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.
Uchiyama2006CuZn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice.
Urushitani2005Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.
Urushitani2002Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis.
Usui2011Overexpression of SOD in retina: need for increase in H2O2-detoxifying enzyme in same cellular compartment.
Vande2008Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.
Vargas2013Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models.
Vargas2011Decreased glutathione accelerates neurological deficit and mitochondrial pathology in familial ALS-linked hSOD1(G93A) mice model.
Vasilaki2010"The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase."
Vila2003Stimulation-induced mitochondrial [Ca2+] elevations in mouse motor terminals: comparison of wild-type with SOD1-G93A. an atlas of gene expression patterns in the mouse embryo.
Vonk2010"Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1."
Vukosavic1999Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis.
Vukosavic2000Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis.
Wada2012Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.
Wakisaka2010Critical role for copper/zinc-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice.
Wang2012"Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and lipogenesis."
Wang2008"Knockouts of Se-glutathione peroxidase-1 and Cu,Zn superoxide dismutase exert different impacts on femoral mechanical performance of growing mice."
Wang2012Ataxin-3 regulates aggresome formation of copper-zinc superoxide dismutase (SOD1) by editing K63-linked polyubiquitin chains.
Wang2003Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature.
Wang2006Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability.
Wang2011Knockout of SOD1 promotes conversion of selenocysteine to dehydroalanine in murine hepatic GPX1 protein.
Wang2010Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrity.
Wang2009Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Wang2009The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis.
Warita1999Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene.
Watanabe2008Adherent monomer-misfolded SOD1.
Watanabe2005Mouse motor neuron disease caused by truncated SOD1 with or without C-terminal modification.
Watson1986"Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans."
Wei2012"Protein misfolding, mitochondrial dysfunction and muscle loss are not directly dependent on soluble and aggregation state of mSOD1 protein in skeletal muscle of ALS."
West2004"Cu,Zn-superoxide dismutase is lower and copper chaperone CCS is higher in erythrocytes of copper-deficient rats and mice."
Weydt2004Increased cytotoxic potential of microglia from ALS-transgenic mice.
Williamson1999Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons.
Womack1986Gene map of the cow: conservation of linkage with mouse and man.
Wong2009"Axonal and neuromuscular synaptic phenotypes in Wld(S), SOD1(G93A) and ostes mutant mice identified by fiber-optic confocal microendoscopy."
Wong1995An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.
Wong1999The genetic and molecular mechanisms of motor neuron disease.
Wu2010"Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritis."
Xing2002"The modulation of cellular susceptibility to oxidative stress: protective and destructive actions of Cu,Zn-superoxide dismutase."
Xiong2005Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase.
Yada2007"Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo."
Yamagishi2007An in vitro model for Lewy body-like hyaline inclusion/astrocytic hyaline inclusion: induction by ER stress with an ALS-linked SOD1 mutation.
Yamanaka2008Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.
Yamanobe2007Deterioration of ischemia/reperfusion-induced acute renal failure in SOD1-deficient mice.
Yang2009Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis.
Ying2009"Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation."
Yon2011Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1+¦ and intracellular superoxide dismutases.
Yon2008Immunohistochemical identification and quantitative analysis of cytoplasmic Cu/Zn superoxide dismutase in mouse organogenesis.
Yon2007The spatio-temporal expression pattern of cytoplasmic Cu/Zn superoxide dismutase (SOD1) mRNA during mouse embryogenesis.
Yonashiro2009Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.
Yoshida2000Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury.
Yoshihara2009Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice.
Yoshii2011Loss of glial fibrillary acidic protein marginally accelerates disease progression in a SOD1(H46R) transgenic mouse model of ALS.
Yu2008Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli.
Yu2011The protective effect of Cu/Zn-SOD against oxidative stress after PTEN deletion.
Yuki2011Retinal ganglion cell loss in superoxide dismutase 1 deficiency.
Zabihi2008Maternal blood glucose levels determine the severity of diabetic embryopathy in mice with different expression of copper-zinc superoxide dismutase (CuZnSOD).
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zelko2002"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression."
Zhai2005HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS.
Zhai2011The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.
Zhang2011Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Zhong2008ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.
Zhu2006"Double null of selenium-glutathione peroxidase-1 and copper, zinc-superoxide dismutase enhances resistance of mouse primary hepatocytes to acetaminophen toxicity."
Zhu2006"Impact of Cu, Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 knockouts on acetaminophen-induced cell death and related signaling in murine liver."
Zhu2008"Role of copper,zinc-superoxide dismutase in catalyzing nitrotyrosine formation in murine liver."
Zhu2010Lipopolysaccharide-induced hepatic oxidative injury is not potentiated by knockout of GPX1 and SOD1 in mice.
Ziv2005Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.
Zou2012Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation.
Zou2007SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity.