GENE OVERVIEW OF ANIMAL MODEL


GeneSigmar1
Gene Namesigma non-opioid intracellular receptor 1
Organism Namemouse
Biological NameMus musculus
Other NamesmSigmaR1|Oprs1
ChromosomeChr4 22.05 cM
Genomic coordinates GRCm37Chr4:41738493-41756157 ( -)
Genomic coordinates GRCm38Chr4:41738493-41756157(-)


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ALL PUBLICATIONS (58)

First_AuthorYearTitle
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Cend+ín2005Formalin-induced pain is reduced in sigma(1) receptor knockout mice.
Chevallier2011"Behavioural phenotyping of knockout mice for the sigma-1 (¤âÔéü) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations."
de2009Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Fontanilla2009"The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator."
Fu2012Fluvoxamine increased glutamate release by activating both 5-HT(3) and sigma-1 receptors in prelimbic cortex of chronic restraint stress C57BL/6 mice.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Gonz+ílez2012Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes.
Gonz+ílez-Cano2013¤â1 receptors are involved in the visceral pain induced by intracolonic administration of capsaicin in mice.
Ha2012Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1.
Ha2011Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (¤âR1).
Harrison1995Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.
Hayashi2001Regulating ankyrin dynamics: Roles of sigma-1 receptors.
Hayashi2007Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Hayashi2003Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export.
Hiramatsu2004Involvement of kappa-opioid receptors and sigma receptors in memory function demonstrated using an antisense strategy.
Ito2011Decreased brain sigma-1 receptor contributes to the relationship between heart failure and depression.
Jiang2006"Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells."
Johannessen2009Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kim2008Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.
King1997Enhanced kappa-opioid receptor-mediated analgesia by antisense targeting the sigma1 receptor.
Kitaichi2001Expression of the purported sigma(1) (sigma(1)) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy.
Kourrich2013Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
Langa2003Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.
Mavlyutov2012"Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N'-dimethyltryptamine forming enzyme, indole-N-methyl transferase."
Mavlyutov2011Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor.
Mavlyutov2010The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. An anatomical and behavioral study.
McMahon2008GUDMAP: the genitourinary developmental molecular anatomy project.
Mei2001Molecular cloning and pharmacological characterization of the rat sigma1 receptor.
Mei2002Sigma1 receptor modulation of opioid analgesia in the mouse.
Navarro2010Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Ola2001Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina.
Ono2013A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells.
Pal2012The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.
Pan1998Cloning and characterization of a mouse sigma1 receptor.
Prause2013"Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis."
Roh2010"Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoforms."
Romieu2002Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade.
Sabino2008Sigma-1 receptor knockout mice display a depressive-like phenotype.
Sansom2009The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Seth1998Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor.
Seth2001Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shioda2012"Expression of a truncated form of the endoplasmic reticulum chaperone protein, ¤â1 receptor, promotes mitochondrial energy depletion and apoptosis."
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Smith2008In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Tagashira2013Stimulation of ¤â1-receptor restores abnormal mitochondrial Ca-¦Ôü¦ mobilization and ATP production following cardiac hypertrophy.
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Watahiki2005Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zhu2003IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunity.