Gene Nameperipherin
Organism Namemouse
Biological NameMus musculus
Other NamesPrph1
ChromosomeChr15 55.72 cM
Genomic coordinates GRCm37Chr15:99055174-99058978 ( +)
Genomic coordinates GRCm38Chr15:99055174-99058978(+)


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Abbott2005"Ectopic HOXA5 expression results in abnormal differentiation, migration and p53-independent cell death of superficial dorsal horn neurons."
Albert2005Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis.
Asahina2012Distribution of protocadherin 9 protein in the developing mouse nervous system.
Bachy2011The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons.
Backer2007Trio controls the mature organization of neuronal clusters in the hindbrain.
Banks2011Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.
Barclay2007"Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain."
Barclay2010Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro.
Beaulieu2004Late onset of motor neurons in mice overexpressing wild-type peripherin.
Beaulieu2003Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins.
Belting1998Multiple phases of expression and regulation of mouse Hoxc8 during early embryogenesis.
Boldogk+Âi2002P2X(3) receptor expression at early stage of mouse embryogenesis.
Britsch2001The transcription factor Sox10 is a key regulator of peripheral glial development.
Buckley2013Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development.
Cacalano1998GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney.
Cariboni2010Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism.
Cariboni2012Slit2 and Robo3 modulate the migration of GnRH-secreting neurons.
Cariboni2011VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Carrillo2008Anti-peripherin B lymphocytes are positively selected during diabetogenesis.
Caubit2010Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control.
Chen2001The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord.
Chien1998Distribution of neuronal intermediate filament proteins in the developing mouse olfactory system.
Chung2008Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons.
Cogliati2007Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies.
Colucci-D'Amato1999Neuronal and glial properties coexist in a novel mouse CNS immortalized cell line.
Coppola2010Epibranchial ganglia orchestrate the development of the cranial neurogenic crest.
Coppola2010Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation.
Coppola2005Reciprocal gene replacements reveal unique functions for Phox2 genes during neural differentiation.
Corradi2002Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.
Couesnon2013CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development.
D'Autr+®aux2011Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.
Dahlstrand1995"Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system."
Dessaud2005"Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development."
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Ding2004Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.
Ding2007Transgenic animal studies of human retinal disease caused by mutations in peripherin/rds.
Durbec1996Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.
Dykes2011Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation.
ElShamy1996A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells.
elshamy1996Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells.
Elstrott2008Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.
Enomoto2000Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.
Erickson1997ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice.
Eriksson2008The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse.
Espana2012Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus.
Faussone-Pellegrini1999The cytoskeleton of the myenteric neurons during murine embryonic life.
Finotto1999Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.
Foley1994The structure of the human peripherin gene (PRPH) and identification of potential regulatory elements.
Forni2011"Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells."
Forni2011A role for FE65 in controlling GnRH-1 neurogenesis.
Furlan2013The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.
Garc+¡a-Frigola2004A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Giacobini2004Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons.
Grimal2010Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells.
Guillemot1993Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons.
Guo2010An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.
Hanania1995Regulation of retinoblastoma gene expression in a mouse mammary tumor model.
Hartman2010Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear.
Heanue2006Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.
Heglind2005Lack of the central nervous system- and neural crest-expressed forkhead gene Foxs1 affects motor function and body weight.
Hirsch1998Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system.
Hong2008Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta.
Honma2010Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret.
Huang2007"Spatiotemporal definition of neurite outgrowth, refinement and retraction in the developing mouse cochlea."
Huang2012"Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea."
Jijiwa2004A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.
Jones1996Close linkage of three neuronal genes on distal mouse chromosome 15.
Kajimura2006Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons.
Karpov1992Structure of the mouse gene encoding peripherin: a neuronal intermediate filament protein.
Karpov1996Three different states of the chromatin structure of the mouse peripherin gene.
Karunadasa2006Expression of pheromone receptor gene families during olfactory development in the mouse: expression of a V1 receptor in the main olfactory epithelium.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kettunen2004"Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme."
Kettunen2007Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning.
Ko1994Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
Kolterud2009Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.
Kramer2000Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha.
Kramer2000Midline nasal tissue influences nestin expression in nasal-placode-derived luteinizing hormone-releasing hormone neurons during development.
Kramer2000Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons.
Kriz2005Up-regulation of peripherin is associated with alterations in synaptic plasticity in CA1 and CA3 regions of hippocampus.
L+©es2003Developmentally regulated expression of Netrin-1 and -3 in the embryonic mouse molar tooth germ.
L+©es2002Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers.
Landon1989"Multiple mRNAs encode peripherin, a neuronal intermediate filament protein."
Larivi+¿re2003Peripherin is not a contributing factor to motor neuron disease in a mouse model of amyotrophic lateral sclerosis caused by mutant superoxide dismutase.
Larivi+¿re2002Reduced number of unmyelinated sensory axons in peripherin null mice.
Leconte1996Cell type-specific expression of the mouse peripherin gene requires both upstream and intragenic sequences in transgenic mouse embryos.
Lee2007Temporal migration of gonadotrophin-releasing hormone-1 neurones is modified in GAD67 knockout mice.
Lek2010A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.
Leung1999The intermediate filament protein peripherin is the specific interaction partner of mouse BPAG1-n (dystonin) in neurons.
Li2013Tissue-specific venous expression of the EPH family receptor EphB1 in the skin vasculature.
Liebl1997"Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice."
Liu1999Myosin VIIa participates in opsin transport through the photoreceptor cilium.
Luo2007A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.
M++ller2003Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.
M++ller2002The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord.
MacDonald2012"Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons."
Madison2004Epithelial hedgehog signals pattern the intestinal crypt-villus axis.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Mandai2009LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
Manji2005Molecular characterization and expression of maternally expressed gene 3 (Meg3/Gtl2) RNA in the mouse inner ear.
Mansouri2000Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9.
Marcos2009Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration.
Marmorstein2007The challenge of modeling macular degeneration in mice.
Masuda2008Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord.
Maz+¦n2005"Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease."
McLean2008A novel peripherin isoform generated by alternative translation is required for normal filament network formation.
McLean2010Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease.
McLean2011Isoform-specific expression and ratio changes accompany oxidant-induced peripherin aggregation in a neuroblastoma cell line.
Messina2011"Dysregulation of Semaphorin7A/+¦1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility."
Mobley2010Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.
Moncla1992Chromosomal localisation of the mouse and human peripherin genes.
Monk2011Gpr126 is essential for peripheral nerve development and myelination in mammals.
Moore1996Renal and neuronal abnormalities in mice lacking GDNF.
Morikawa2007Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system.
Morin1997Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a.
Nagashimada2012Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression.
Nagata2010Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions.
Nishino2010Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.
Nour2008Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa.
Odemis2005Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis.
Ohshima2002Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Parisi2003Genetic background modifies intestinal pseudo-obstruction and the expression of a reporter gene in Hox11L1-/- mice.
Pattyn2003Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.
Pattyn2000Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.
Pattyn1997Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis.
Pattyn1999The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives.
Pendleton1991The peripherin gene maps to mouse chromosome 15.
Pernas-Alonso1995Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse.
Pi+¦on1996"Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling."
Puertas2007Peripherin is a relevant neuroendocrine autoantigen recognized by islet-infiltrating B lymphocytes.
Quina2012Hmx1 is required for the normal development of somatosensory neurons in the geniculate ganglion.
Rao2002Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density.
Rebelo2006Involvement of DRG11 in the development of the primary afferent nociceptive system.
Riethmacher1997Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Robertson2003A neurotoxic peripherin splice variant in a mouse model of ALS.
Rush2005Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons.
Rutherford2004Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina.
Schmidt2009C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.
Schmidt2007The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.
Schwarting2001Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain.
Schwarting2004Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons.
Shah1996Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shirane2008Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.
Sommer1995The cellular function of MASH1 in autonomic neurogenesis.
Sonnenberg-Riethmacher2001Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Subramanian2007A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis.
Sun2003Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion.
Taylor2007Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.
Temple2005Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system.
Tiveron2003Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus.
Toba2005Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.
Usui2012Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation.
Velkey2013Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
Vigers2003Neurotrophin-3 is expressed in a discrete subset of olfactory receptor neurons in the mouse.
Walter1995"Identification of a novel conserved human gene, TEGT."
Wende2012The transcription factor c-Maf controls touch receptor development and function.
Wickramasinghe2008Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.
Wildner2013Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity.
Wray1994A subset of peripherin positive olfactory axons delineates the luteinizing hormone releasing hormone neuronal migratory pathway in developing mouse.
Yanagisawa1998Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene.
Yuan2012Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons.
Zhao2012The effects of bilateral common carotid artery occlusion on expression of peripherin and choline acetyltransferase activity in C57BL/6 mice.
Zhou2002Murine peripherin gene sequences direct Cre recombinase expression to peripheral neurons in transgenic mice.
Zou2012Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord.