Gene Nameprofilin 1
Organism Namemouse
Biological NameMus musculus
Other Namesactin binding protein|Pfn
ChromosomeChr11 43.21 cM
Genomic coordinates GRCm37Chr11:70651850-70654644 ( -)
Genomic coordinates GRCm38Chr11:70651850-70654644(-)


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B÷ttcher2009Profilin 1 is required for abscission during late cytokinesis of chondrocytes.
Bonaldo1996Normalization and subtraction: two approaches to facilitate gene discovery.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Coppinger2003Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.
Dong2004Entorhinal deafferentation induces the expression of profilin mRNA in the reactive microglial cells in the hippocampus.
Fan2012Stimulus-dependent phosphorylation of profilin-1 in angiogenesis.
G+Ârlich2012Preserved morphology and physiology of excitatory synapses in profilin1-deficient mice.
Gareus2005Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Gertler1996"Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics."
Giesemann2003"Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system."
Gogstad1981Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.
J+®gou2011Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilin.
Jiang1998"Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein."
Jin2012"ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production."
Johnsson2010Microtubule-dependent localization of profilin I mRNA to actin polymerization sites in serum-stimulated cells.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Klingenspor1997Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively.
Koblansky2012Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Kullmann2011Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons.
Kullmann2012Purkinje cell loss and motor coordination defects in profilin1 mutant mice.
Kwiatkowski1988"Human profilin. Molecular cloning, sequence comparison, and chromosomal analysis."
Kwiatkowski1990"Identification of the functional profilin gene, its localization to chromosome subband 17p13.3, and demonstration of its deletion in some patients with Miller-Dieker syndrome."
Lanier1999Mena is required for neurulation and commissure formation.
Laochumroonvorapong1997"Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice."
Lederer2004"Profilin regulates the activity of p42POP, a novel Myb-related transcription factor."
Miyagi2002Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.
Miyajima2012Profilin1 regulates sternum development and endochondral bone formation.
Morris1993Somatic cell hybrid mapping on mouse chromosome 11 (MMU11): assignment of markers relative to two breakpoints in band D.
Moustafa-Bayoumi2007Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1.
Murphy1999"Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth."
Neuhoff2005The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Romeo2007Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse.
Romero2007How ATP hydrolysis controls filament assembly from profilin-actin: implication for formin processivity.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Takenaka1998Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.
Verlaet2001Genetic imbalances in preleukemic thymuses.
Watters2001"Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11."
Widada1989Total coding sequence of profilin cDNA from Mus musculus macrophage.
Witke1995"Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin."
Witke1998In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.
Witke2001Profilin I is essential for cell survival and cell division in early mouse development.
Wittenmayer2004Tumor suppressor activity of profilin requires a functional actin binding site.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.