Gene Nameoptineurin
Organism Namemouse
Biological NameMus musculus
Other Names4930441O07Rik|TFIIIA-INTP
ChromosomeChr2 3.15 cM
Genomic coordinates GRCm37Chr2:5020642-5064051 ( -)
Genomic coordinates GRCm38Chr2:5020642-5064051(-)


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Brunskill2011Defining the molecular character of the developing and adult kidney podocyte.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Chi2010Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice.
De2006Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus.
Deng2011Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Gleason2011Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon +¦.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kroeber2006Transgenic studies on the role of optineurin in the mouse eye.
Li2008A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Miyamoto-Sato2005Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein-protein interactions and complexes.
Moreland2000Identification of a transcription factor IIIA-interacting protein.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Okita2011Cell type-specific localization of optineurin in the striatal neurons of mice: implications for neuronal vulnerability in Huntington's disease.
Rezaie2004"Molecular cloning, genomic structure, and protein characterization of mouse optineurin."
Rezaie2007Embryonic expression of the optineurin (glaucoma) gene in different stages of mouse development.
Shen2010Processing of optineurin in neuronal cells.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Sippl2011Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." an atlas of gene expression patterns in the mouse embryo.
Visel2007Regulatory pathway analysis by high-throughput in situ hybridization.
Watahiki2005Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zhu2007Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.