GENE OVERVIEW OF ANIMAL MODEL


GeneFus
Gene Namefused in sarcoma
Organism Namemouse
Biological NameMus musculus
Other NamesD430004D17Rik|D930039C12Rik|hnRNP P2|pigpen|Tls|translocated in liposarcoma
ChromosomeChr7 69.87 cM
Genomic coordinates GRCm37Chr7:127967457-127982368 ( +)
Genomic coordinates GRCm38Chr7:127967457-127982368(+)


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ALL PUBLICATIONS (62)

First_AuthorYearTitle
Alappat2003Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis.
Ballif2006Identification of 14-3-3epsilon substrates from embryonic murine brain.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Chen2008The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.
Cironi2008IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
Colombrita2012TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.
Doi2008RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
Fratta2012FUS is not dysregulated by the spinal bulbar muscular atrophy androgen receptor polyglutamine repeat expansion.
Fujii2005The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
Fujii2005TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines.
Gal2010Nuclear localization sequence of FUS and induction of stress granules by ALS mutants.
Gardiner2008Identification and characterization of FUS/TLS as a new target of ATM.
Georgas2009Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Gray2004Mouse brain organization revealed through direct genome-scale TF expression analysis.
Hansen2003"A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome."
Hicks2000"Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death."
Huang2010Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
Husi2000Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Ishigaki2012Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions.
Jensen2004A neurogenomics approach to gene expression analysis in the developing brain.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kino2010Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Kornmann2007System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
Kuroda1999Induction of a secreted protein by the myxoid liposarcoma oncogene.
Kuroda2000Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
Lagier-Tourenne2012Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Lanson2012FUS-related proteinopathies: lessons from animal models.
Lepourcelet2004Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF).
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Mathew2012BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
McKee2005A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
McMahon2008GUDMAP: the genitourinary developmental molecular anatomy project.
Melot2001Characterization of a new brain-specific isoform of the EWS oncoprotein.
Mencinger1999Characterization of TFG in mus musculus and Caenorhabditis elegans.
Nakaya2013FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Orozco2012Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
Pan2008TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.
Rodriguez2011FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.
Rogelj2012Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain.
S+ínchez-Ramos2011PGC-1+¦ regulates translocated in liposarcoma activity: role in oxidative stress gene expression.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Sugawara2010FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Takarada2009"A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus."
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Tauffenberger2012"Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models."
Thomsen2012Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and function.
Tradewell2011Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.
Uzhachenko2012Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasis.
Visel2003GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Wang2008Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
Yamaguchi2012"The effect of PRMT1-mediated arginine methylation on the subcellular localization, stress granules, and detergent-insoluble aggregates of FUS/TLS."
Yang1998Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.
Yokoyama2010A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yoshida2010"Pigpen, a nuclear coiled body component protein, is involved in angiogenesis."
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.