GENE OVERVIEW OF ANIMAL MODEL


GeneFig4
Gene NameFIG4 homolog (S. cerevisiae)
Organism Namemouse
Biological NameMus musculus
Other NamesA530089I17Rik
ChromosomeChr10 22.08 cM
Genomic coordinates GRCm37Chr10:41188172-41303241 ( -)
Genomic coordinates GRCm38Chr10:41188172-41303241(-)


BIOINFORMATICS

Entrez Gene   UCSC Browser      OMIM   KEGG   Full Literature        
 

ALL PUBLICATIONS (29)

First_AuthorYearTitle
Bonaldo1996Normalization and subtraction: two approaches to facilitate gene discovery.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Chow2007Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Ferguson2009"Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2."
Ferguson2012Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Guo2011Fig4 expression in the rodent nervous system and its potential role in preventing abnormal lysosomal accumulation.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Ikonomov2009"Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes."
Ikonomov2010ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
Katayama2005Antisense transcription in the mammalian transcriptome.
Katona2011Distinct pathogenic processes between Fig4-deficient motor and sensory neurons.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Khuda2004The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells.
Lenk2011Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Okazaki2004Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Vaccari2011Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.
Watahiki2005Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Winters2011"Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4."
Yan2011Trauma does not accelerate neuronal degeneration in Fig4 insufficient mice.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zhang2012"Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)PÔéé and PI(5)P."
Zolov2012"In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P."