Gene NameErbB4|Her4
Organism Namemouse
Biological NameMus musculus
Other Names 
ChromosomeChr1 33.80 cM
Genomic coordinates GRCm37Chr1:68032186-69108059(-)
Genomic coordinates GRCm38Chr1:68032186-69108059(-)


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Abe2009In situ hybridization reveals developmental regulation of ErbB1-4 mRNA expression in mouse midbrain: implication of ErbB receptors for dopaminergic neurons.
Ahn2013Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.
Anton2004Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain.
Aqeilan2005WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.
Bao2003Back signaling by the Nrg-1 intracellular domain.
Barros2009Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.
Bersell2009Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.
Bian2009[The correlation between ketamine-induced schizophrenia-like signs in mice and the expressions of NRG1, ErbB4 mRNA].
Bjarnadottir2007Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.
Bovetti2006Differential expression of neuregulins and their receptors in the olfactory bulb layers of the developing mouse.
Brinkmann2008Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.
Brown2004Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse.
Cahill2011Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition.
Calaora2001Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Caronia-Brown2010Timing of cortical interneuron migration is influenced by the cortical hem.
Carraway1996Involvement of the neuregulins and their receptors in cardiac and neural development.
Carraway1997Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
Chan2004Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development.
Chen2003Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.
Chen2010ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation.
Chen2010Intramembranous valine linked to schizophrenia is required for neuregulin 1 regulation of the morphological development of cortical neurons.
Chen2006Neuregulin 1-erbB signaling is necessary for normal myelination and sensory function.
Cheng2003Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment.
Choi2011Monosynaptic inputs to ErbB4-expressing inhibitory neurons in mouse primary somatosensory cortex.
Choi2010Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor-ligand bridge protein.
Clark2005ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.
Cobos2007Dlx transcription factors promote migration through repression of axon and dendrite growth.
Cooley2011Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation.
Dackor2007Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos.
de2006Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Elenius1997A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.
Endoh-Yamagami2010A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
Escher2005Synapses form in skeletal muscles lacking neuregulin receptors.
Fazzari2010Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.
Feng2008The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation.
Fisahn2008Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia.
Flames2004Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1.
Fox2005Developmental profile of ErbB receptors in murine central nervous system: implications for functional interactions.
Frey2010ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells.
Frey2008The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF.
Fried2002Expression of ErbB3, ErbB4, and neuregulin-1 mRNA during tooth development.
Gajendran2009Neuregulin signaling is dispensable for NMDA- and GABA(A)-receptor expression in the cerebellum in vivo.
Garc+¡a-Rivello2005Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle.
Gassmann1995Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.
Ghashghaei2006The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone.
Gilmore-Hebert2010Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.
Golding1999Chondroitin sulphate-binding molecules may pattern central projections of sensory axons within the cranial mesenchyme of the developing mouse.
Golding2000Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.
Golding2004Heparin-binding EGF-like growth factor shows transient left-right asymmetrical expression in mouse myotome pairs.
Golding2004Roles of erbB4, rhombomere-specific, and rhombomere-independent cues in maintaining neural crest-free zones in the embryonic head.
Golub2004Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse.
Grego-Bessa2007Notch signaling is essential for ventricular chamber development.
Harmelink2012Myocardial Mycn is essential for mouse ventricular wall morphogenesis.
Herbst2002Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.
Higa-Nakamine2011Selective cleavage of ErbB4 by G-protein-coupled gonadotropin-releasing hormone receptor in cultured hypothalamic neurons.
Hoeing2011Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation.
Horie2010Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway.
Howard2005Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification.
Huang2012Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.
Huotari2002ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture.
Icli2012ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
Inaki2004Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules.
Iwamoto2003Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function.
Jackson-Fisher2006Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4.
Jiang2005Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation.
Jones1999ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kramer1996Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.
Krivosheya2008ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms.
Kroll2005Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate.
L+¦pez-Bendito2006Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation.
Lai2010Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.
Lemmens2007Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure.
Li2011Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Li2012Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations.
Licatalosi2012Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Lim1998erbB genes in the mouse uterus: cell-specific signaling by epidermal growth factor (EGF) family of growth factors during implantation.
Ling2011An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer.
Liu2010ErbB4 regulates the timely progression of late fetal lung development.
Liu2004Neuregulin-1 induces branching morphogenesis in the developing lung through a P13K signal pathway.
Long2007Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
Long2009Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.
Long2008Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
Long2003Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.
Longart2007Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons.
Lorita2009ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.
Lynch2007Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor.
Madisen2009A robust and high-throughput Cre reporting and characterization system for the whole mouse brain.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Meixner2010Jun and JunD-dependent functions in cell proliferation and stress response.
Meyer1997Isoform-specific expression and function of neuregulin.
Meyer1995Multiple essential functions of neuregulin in development.
Miettinen2000Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.
Miyazaki2004Tissue interaction mediated by neuregulin-1 and ErbB receptors regulates epithelial morphogenesis of mouse embryonic submandibular gland.
Moscoso1995Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.
Muraoka-Cook2009ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.
Muraoka-Cook2008Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation.
Muraoka-Cook2006The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.
Murphy2008Neuregulin signaling in neurons depends on ErbB4 interaction with PSD-95.
Mysliwiec2011Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.
Nawachi2002Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
Nebigil2000Serotonin 2B receptor is required for heart development.
Neddens2009Selective populations of hippocampal interneurons express ErbB4 and their number and distribution is altered in ErbB4 knockout mice.
Okazaki2002Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Olsen2005Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex.
Ortega2012Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.
Paatero2012Interaction with ErbB4 promotes hypoxia-inducible factor-1+¦ signaling.
Paria1999Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation.
Pitcher2008ErbB4 is a suppressor of long-term potentiation in the adult hippocampus.
Plowman1993Heregulin induces tyrosine phosphorylation of HER4/p180erbB4.
Prevot2004erbB-1 and erbB-4 receptors act in concert to facilitate female sexual development and mature reproductive function.
Prevot2003Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes.
Purevdorj2008ErbB4 deletion leads to changes in lung function and structure similar to bronchopulmonary dysplasia.
Riese1998Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2.
Riese1996The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4.
Rio1997Neuregulin and erbB receptors play a critical role in neuronal migration.
Robinson2000The protein tyrosine kinase family of the human genome.
Rokicki2010The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium.
Saito2012Mab21l2 is essential for embryonic heart and liver development.
Sandau2011SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development.
Sardi2006Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.
Savonenko2008Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.
Schmidt2011Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of +¦-dystrobrevin.
Schmiedl2011Lipopolysaccharide-induced injury is more pronounced in fetal transgenic ErbB4-deleted lungs.
Schwarz2008Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells.
Sessa2010Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons.
Shamir2012The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders.
Shi2003TACE is required for fetal murine cardiac development and modeling.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shu2003The glial sling is a migratory population of developing neurons.
Smith2001Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.
Soo2002Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.
Stefansson2002Neuregulin 1 and susceptibility to schizophrenia.
Suk2003Expression of ErbB receptors in ES cell-derived cardiomyocytes.
Sundvall2010Cell death or survival promoted by alternative isoforms of ErbB4.
Sussman2005The ErbB4 neuregulin receptor mediates suppression of oligodendrocyte maturation.
Tan2011Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
Tanaka1999The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.
Thuret2004Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.
Thuret2004The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta.
Tidcombe2003Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality.
Ting2011Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.
van2013Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.
Vasudevan2009Fertility comparison between wild type and transgenic mice by in vitro fertilization.
Veikkolainen2011ErbB4 modulates tubular cell polarity and lumen diameter during kidney development.
Verma-Kurvari2004Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Vullhorst2009Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus.
Walker1998The erbB/HER type 1 tyrosine kinase receptor family.
Wang2010Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.
Wang1998Temporal and spatial expression of erbB4 in ectodermal and mesenchymal cells during primary palatogenesis in noncleft and cleft strains of mice.
Wansbury2007Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.
Watanabe2006Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.
Wen2010Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons.
Wolpowitz2000Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses.
Wrobel2007Persistent expression of stabilized beta-catenin delays maturation of radial glial cells into intermediate progenitors.
Xu2012Neuregulin1+¦1 protects oligodendrocyte progenitor cells from oxygen glucose deprivation injury induced apoptosis via ErbB4-dependent activation of PI3-kinase/Akt.
Ying2009The protocadherin gene Celsr3 is required for interneuron migration in the mouse forebrain.
Zhang1997Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.
Zscheppang2011Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells.
Zscheppang2011Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung.