GENE OVERVIEW OF ANIMAL MODEL


GeneAtxn2
Gene Nameataxin 2
Organism Namemouse
Biological NameMus musculus
Other Names9630045M23Rik|ATX2|Sca2
ChromosomeChr5 61.93 cM
Genomic coordinates GRCm37Chr5:121711337-121816493 ( +)
Genomic coordinates GRCm38Chr5:121711337-121816493(+)


BIOINFORMATICS

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ALL PUBLICATIONS (33)

First_AuthorYearTitle
Aguiar2005Ubiquitous expression of human SCA2 gene under the regulation of the SCA2 self promoter cause specific Purkinje cell degeneration in transgenic mice.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Cotney2012Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limb.
Crozet1997Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.
Damrath2012ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Hansen2003"A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome."
Hansen2012Changes in Purkinje cell firing and gene expression precede behavioral pathology in a mouse model of SCA2.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Huynh2009Dissociated fear and spatial learning in mice with deficiency of ataxin-2.
Huynh2000Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human.
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawaguchi1994CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kiehl2005Generation and characterization of Sca2 (ataxin-2) knockout mice.
Kiehl2001Identification and expression of a mouse ortholog of A2BP1.
Lastres-Becker2008Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
Lord-Grignon2006Identification of genes expressed in retinal progenitor/stem cell colonies isolated from the ocular ciliary body of adult mice.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Nechiporuk1998"The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression."
Nonis2008Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Orr2000The ins and outs of a polyglutamine neurodegenerative disease: spinocerebellar ataxia type 1 (SCA1).
Pulst1996Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
Ralser2005Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.
Rudra2012Transcription factor Foxp3 and its protein partners form a complex regulatory network.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.