GENE OVERVIEW OF ANIMAL MODEL


GeneAls2
Gene Nameamyotrophic lateral sclerosis 2 (juvenile)
Organism Namemouse
Biological NameMus musculus
Other Names3222402C23Rik|9430073A21Rik|Als2cr6|Alsin|mKIAA1563
ChromosomeChr1 29.33 cM
Genomic coordinates GRCm37Chr1:59162926-59237231 ( -)
Genomic coordinates GRCm38Chr1:59162926-59237231(-)


BIOINFORMATICS

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ALL PUBLICATIONS (50)

First_AuthorYearTitle
+çobano-ƒlu2012Are alsin and spartin novel interaction partners?
Bonaldo1996Normalization and subtraction: two approaches to facilitate gene discovery.
Cai2005Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress.
Carninci1999High-efficiency full-length cDNA cloning.
Carninci2000Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci2005The transcriptional landscape of the mammalian genome.
Chandran2007Alsin and the molecular pathways of amyotrophic lateral sclerosis.
Deng2007Distal axonopathy in an alsin-deficient mouse model.
Devon2006Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.
Diez-Roux2011A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Enunlu2011Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Erie2006Mice deficient in the ALS2 gene exhibit lymphopenia and abnormal hematopietic function.
Evsikov2006Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Gerhard2004"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Gros-Louis2008Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.
Hadano2001A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Hadano2010Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.
Hadano2010Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
Hadano2005Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.
Hansen2008Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Jacquier2006Alsin/Rac1 signaling controls survival and growth of spinal motoneurons.
Jacquier2009Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2/alsin function.
Kanekura2004"A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death."
Katayama2005Antisense transcription in the mammalian transcriptome.
Kawai2001Functional annotation of a full-length mouse cDNA collection.
Kress2005Novel mutation in the ALS2 gene in juvenile amyotrophic lateral sclerosis.
Kunita2007The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis.
Lai2006Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Lai2009Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
Li2011Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity.
Lin2006Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice.
Magdaleno2006BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Millecamps2005Alsin is partially associated with centrosome in human cells.
Nadeau2003Modifier genes and protective alleles in humans and mice.
Okazaki2002"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
Okazaki2003Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Otomo2008ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth.
Pan2012"Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice."
Piao2001Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Railo2009Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets.
Sharov2003Transcriptome analysis of mouse stem cells and early embryos.
Shibata2000RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Skarnes2011A conditional knockout resource for the genome-wide study of mouse gene function.
Strausberg2002"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
Stryke2003BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Suzuki-Utsunomiya2007"ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics."
Tanaka2000"Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray."
Topp2004Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.
Yamanaka2006Progressive spinal axonal degeneration and slowness in ALS2-deficient mice.
Zambrowicz2003Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.