GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneVEGFA
Other namesVPF; VEGF; VEGF-A; MGC70609
Gene namevascular endothelial growth factor A
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryEXOTOXICITY AND GLUTAMATE TRANSPORT
Chromosome6p12
GRCh37 (hg19)Chr6:43737946-43754224 ( +)
GRCh38 (hg38)Chr6:43770209-43786487(+)
BackgroundSusceptibility
ResultAssociation found in some populations
Mutations0
Patients0

BIOINFORMATICS

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Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

TOP META-ANALYSIS RESULT FROM ALSGENE

For more details on this and other meta-analysis results in this region please visit the ALSGene database

ANIMAL MODELS

                               

KEY PUBLICATIONS (16)

First_AuthorYearTitlePaper
Brockington2005Screening of the regulatory and coding regions of vascular endothelial growth factor in amyotrophic lateral sclerosisFull_Paper
Chen2006Lack of association of VEGF promoter polymorphisms with sporadic ALSFull_Paper
Chen2007Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosisFull_Paper
Chen2007Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosisFull_Paper
Corcia2006SMN1 gene, but not SMN2, is a risk factor for sporadic ALSFull_Paper
Del Bo2008Absence of angiogenic genes modification in Italian ALS patientsFull_Paper
Fernandez-Santiago2006Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALSFull_Paper
Golenia2010Lack of association between VEGF gene polymorphisms and plasma VEGF levels and sporadic ALFull_Paper
Lambrechts2003VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic deathFull_Paper
Oosthuyse2001Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degenerationFull_Paper
Takahashi2008Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosisFull_Paper
Terry2004VEGF promoter haplotype and amyotrophic lateral sclerosis (ALS)Full_Paper
Tolosa2007Vascular endothelial growth factor protects spinal cord motoneurons against glutamate-induced excitotoxicity via phosphatidylinositol 3-kinaseFull_Paper
Van Vught2005Lack of association between VEGF polymorphisms and ALS in a Dutch populationFull_Paper
Wang2007Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis miceFull_Paper
Zhang2006VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patientsFull_Paper