GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneSOD2
Other namesIPO-B; MNSOD; Mn-SOD
Gene namesuperoxide dismutase 2, mitochondrial
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryOXIDATIVE STRESS
Chromosome6q25
GRCh37 (hg19)Chr6:160100148-160114353 ( -)
GRCh38 (hg38)Chr6:159679116-159693321(-)
BackgroundSOD2 is a related protein of SOD1, found in mitochondria
ResultNo association with human ALS demonstrated/ replicated
Mutations0
Patients0

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ANIMAL MODELS

                               

KEY PUBLICATIONS (4)

First_AuthorYearTitlePaper
Skvortsova2004Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND)Full_Paper
Tomblyn1998Distribution of MnSOD polymorphisms in sporadic ALS patientsFull_Paper
Tomkins2001Mutation screening of manganese superoxide dismutase in amyotrophic lateral sclerosisFull_Paper
Van Lendeghem1999Manganese-containing superoxide dismutase signal sequence polymorphism associated with sporadic motor neuron diseaseFull_Paper