GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneSNCG
Other namesSR; BCSG1
Gene namesynuclein, gamma (breast cancer-specific protein 1)
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryNEUROFILAMENTS, CYTOSKELETON AND MICROTUBULE DEFECTS
Chromosome10q23.2-q23.3
GRCh37 (hg19)Chr10:88718288-88723017 ( +)
GRCh38 (hg38)Chr10:86957774-86963260(+)
BackgroundPersyn is a member of the synuclein family, ?-synuclein. Mutations in a-synuclein found in Parkinson's disease
ResultNo association with human ALS demonstrated/ replicated
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Flowers1999Mutations in the gene encoding human persyn are not associated with amyotrophic lateral sclerosis or familial Parkinson's diseaseFull_Paper