GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneRNF19A
Other namesRNF19; DORFIN; DKFZp566B1346; RNF19A
Gene namering finger protein 19A
Gene inheritanceSALS genes
Discovery methodGWAS
Category 
Chromosome8q22
GRCh37 (hg19)Chr8:101269288-101322379 ( -)
GRCh38 (hg38)Chr8:100257057-100336218(-)
BackgroundTo analyze the genes related to the pathophysiology of sporadic amyotrophic lateral sclerosis (SALS)
ResultGenes associated with the ubiquitin-proteasome system, oxidative toxicity, transcription, neuronal differentiation and inflammation might be involved in the pathogenesis of SALS
Mutations0
Patients0

BIOINFORMATICS

Entrez Gene  UCSC Browser  Protein Structure  OMIM  Genecards  Full Literature  ProtScale  Sequence    Uniprot
iHop  Pathway  GeneTest  ALS review                  Animal models
GeneMANIA  AmiGO  Gene Wiki  Wolfram Alpha  Ensembl  NCBI  WikiGenes    ALSGene    GeneNetwork
Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Ishigaki2006Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicityFull_Paper