GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GenePVR
Other namesPVS; HVED; CD155; NECL5; TAGE4; Necl-5
Gene namePoliovirus receptor
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryOTHER PROCESSES
Chromosome19q13.2
GRCh37 (hg19)Chr19:45147098-45169429 ( +)
GRCh38 (hg38)Chr19:44643798-44666161(+)
BackgroundPoliovirus attacks motor neurons selectively, enteroviral nucleic acids found in spinal cord of ALS patients
ResultAssociation with lower motor neuron disease found in one small study, not yet replicated
Mutations0
Patients0

BIOINFORMATICS

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Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Saunderson2004A polymorphism in the poliovirus receptor gene differs in motor neuron diseaseFull_Paper