GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GenePON2
Other names"paraoxonase nirs"
Gene nameparaoxonase 2
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryPOOR METABOLISM OF XENOBIOTICS
Chromosome7q21.3
GRCh37 (hg19)Chr7:95034174-95064384 ( -)
GRCh38 (hg38)Chr7:95404862-95435072(-)
BackgroundMajor protective role both against environmental toxins and as part of the antioxidant defence system
ResultEvidence that genetic variation across the paroxanase loci may be susceptibility factors for SALS.
Mutations0
Patients0

BIOINFORMATICS

Entrez Gene  UCSC Browser  Protein Structure  OMIM  Genecards  Full Literature  ProtScale  Sequence    Uniprot
iHop  Pathway  GeneTest  ALS review                  Animal models
GeneMANIA  AmiGO  Gene Wiki  Wolfram Alpha  Ensembl  NCBI  WikiGenes  Life Science DB(Japan)  ALSGene    GeneNetwork
Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

TOP META-ANALYSIS RESULT FROM ALSGENE

For more details on this and other meta-analysis results in this region please visit the ALSGene database

ANIMAL MODELS

                               

KEY PUBLICATIONS (10)

First_AuthorYearTitlePaper
Cronin2007Paraoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosisFull_Paper
Kasperaviciute2007Large-scale pathways-based association study in amyotrophic lateral sclerosisFull_Paper
Landers2008A common haplotype within the PON1 promoter region is associated with sporadic ALSFull_Paper
Penco2008New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroundFull_Paper
Ricci2010Lack of association of PON polymorphisms with sporadic ALS in an Italian populationFull_Paper
Saeed2006Paraoxonase cluster polymorphisms are associated with sporadic ALSFull_Paper
Saeed2006Paraoxonase cluster polymorphisms are associated with sporadic ALSFull_Paper
Slowik2006Paraoxonase gene polymorphisms and sporadic ALSFull_Paper
Ticozzi2010Paraoxonase gene mutations in amyotrophic lateral sclerosisFull_Paper
Valdmanis2008Association of paraoxonase gene cluster polymorphisms with ALS in France, Quebec, and SwedenFull_Paper