GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneOGG1
Other namesHMMH; MUTM; OGH1; HOGG1; OGG1
Gene name8-oxoguanine DNA glycosylase
Gene inheritanceSALS genes
Discovery methodGWAS
Category 
Chromosome3p26
GRCh37 (hg19)Chr3:9791628-9808353 ( +)
GRCh38 (hg38)Chr3:9749944-9787790(+)
BackgroundTo evaluate the role of the hOGG1 Ser326Cys polymorphism in sporadic ALS (sALS) as gene is associated with a reduced DNA repair activity
ResultA possible involvement of the hOGG1 Ser326Cys polymorphism in sALS pathogenesis
Mutations0
Patients0

BIOINFORMATICS

Entrez Gene  UCSC Browser  Protein Structure  OMIM  Genecards  Full Literature  ProtScale  Sequence    Uniprot
iHop  Pathway  GeneTest  ALS review                  Animal models
GeneMANIA  AmiGO  Gene Wiki  Wolfram Alpha  Ensembl  NCBI  WikiGenes    ALSGene    GeneNetwork
Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Coppede2007Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosisFull_Paper