GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneNAIP
Other namesBIRC1; NLRB1; psiNAIP; FLJ42520
Gene nameNLR family, apoptosis inhibitory protein
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome5q13.1
GRCh37 (hg19)Chr5:70264310-70320941 ( -)
GRCh38 (hg38)Chr5:70968483-71025114(-)
BackgroundNAIP involved in related disease, spinal muscular atrophy
ResultNo association. Mutations in NAIP now considered specific for SMA
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (5)

First_AuthorYearTitlePaper
Jackson1996Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: homozygous NAIP deletion in a sporadic caseFull_Paper
Kunst2000Genetic mapping of a mouse modifier gene that can prevent ALS onsetFull_Paper
Orrell1997The relationship of spinal muscular atrophy to motor neuron disease: investigation of SMN and NAIP gene deletions in sporadic and familial ALSFull_Paper
Parboosingh1999Deletions causing spinal muscular atrophy do not predispose to amyotrophic lateral sclerosisFull_Paper
Pari2000Immunolocalization of NAIP in the human brain and spinal cordFull_Paper