GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneMAOB
Other namesMGC26382
Gene namemonoamine oxidase B
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryPOOR METABOLISM OF XENOBIOTICS
ChromosomeXp11.4
GRCh37 (hg19)ChrX:43625857-43741721 ( -)
GRCh38 (hg38)ChrX:43766610-43882475(-)
BackgroundMAO-B generates free radicals and these are implicated in neuronal damage
ResultAssociation with age at onset modification reported, not yet replicated
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Orru1999Association of monoamine oxidase B alleles with age at onset in amyotrophic lateral sclerosisFull_Paper