GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneLOX
Other namesMGC105112
Gene namelysyl oxidase
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryPOOR METABOLISM OF XENOBIOTICS
Chromosome5q23.2
GRCh37 (hg19)Chr5:121398890-121414055 ( -)
GRCh38 (hg38)Chr5:122063195-122078360(-)
BackgroundLOX is a copper containing enzyme and copper-induced cytotoxicity is a hypothetical mechanism of motor neuron degeneration
ResultNo association with human ALS demonstrated/ replicated
Mutations0
Patients0

BIOINFORMATICS

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Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Chioza2001Mutations in the lysyl oxidase gene are not associated with amyotrophic lateral sclerosisFull_Paper