GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneLIF
Other namesCDF; HILDA; D-FACTOR
Gene nameleukemia inhibitory factor (cholinergic differentiation factor)
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome22q12.2
GRCh37 (hg19)Chr22:30636436-30642840 ( -)
GRCh38 (hg38)Chr22:30240447-30257381(-)
BackgroundLIF is same cytokine family as CNTF, involved in motor neuron survival
ResultOne reported association, not yet replicated
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (3)

First_AuthorYearTitlePaper
Giess2000Potential role of LIF as a modifier gene in the pathogenesis of amyotrophic lateral sclerosisFull_Paper
Kihira2007Expression of insulin-like growth factor-II and leukemia inhibitory factor antibody immunostaining on the ionized calcium-binding adaptor molecule 1-positive microglias in the spinal cord of amyotrophic lateral sclerosis patientsFull_Paper
Meyer1995ALS and chromosome 22: evidence for a possible neurofilament gene defectFull_Paper