GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneKIFAP3
Other namesKAP3; SMAP; Smg-GDS; FLJ22818; dJ190I16.1; KIFAP3
Gene namekinesin-associated protein 3
Gene inheritancePhenotype-modifying genes
Discovery methodGWAS
Category 
Chromosome1p36.13-q31.3
GRCh37 (hg19)Chr1:169890470-170043879 ( -)
GRCh38 (hg38)Chr1:169921329-170074741(-)
BackgroundKIFAP3 was implicated in modifying survival in a large genome-wide association study of ALS.
ResultThree of the top five hits were of variants in the KIFAP3 gene. Sensitivity analysis supports the association as replicating in several different populations.
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (2)

First_AuthorYearTitlePaper
Landers2009Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosisFull_Paper
Traynor2010Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patientsFull_Paper