GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneKDR
Other namesFLK1; CD309; VEGFR; VEGFR2; KDR
Gene namekinase insert domain receptor (a type III receptor tyrosine kinase)
Gene inheritanceSALS genes
Discovery methodGWAS
Category 
Chromosome4q11-q12
GRCh37 (hg19)Chr4:55944426-55991762 ( -)
GRCh38 (hg38)Chr4:55078259-55125595(-)
BackgroundDysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and expression of VEGFR2 is reduced in motor neurones and spinal cord of patients with ALS
ResultFound no association between polymorphisms in the regulatory regions of the VEGFR2 gene and ALS
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Brockington2007Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosisFull_Paper