GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneDPP6
Other namesVF2; DPPX; FLJ55680; MGC46605; DPP6
Gene namedipeptidyl-peptidase 6
Gene inheritanceSALS genes
Discovery methodGWAS
Category 
Chromosome7q36.2
GRCh37 (hg19) 
GRCh38 (hg38)Chr7:153748189-154894285(+)
Background 
Result 
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (8)

First_AuthorYearTitlePaper
Cronin2007A genome-wide association study of sporadic ALS in a homogenous Irish population Hum Mol Genet 2008;17:768-74Full_Paper
Cronin2008Screening for replication of genome-wide SNP associations in sporadic ALS Eur J Hum Genet 2009 Feb;17(2):213-8 Epub 2008 Nov 5Full_Paper
Daoud2010Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosisFull_Paper
Daoud2010Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral SclerosisFull_Paper
Del Bo2008DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patientsFull_Paper
Fogh2009No association of DPP6 with amyotrophic lateral sclerosis in an Italian population Full_Paper
Li2009Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patientsFull_Paper
van Es2007Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosisFull_Paper

GENETIC VARIATIONS

SNP (rs)BasepairpvalueAuthorYearTermPaper
 102604041542107983E-06Cronin2007GRCh37A genome-wide association study of sporadic ALS in a homogenous Irish population Hum Mol Genet 2008;17:768-74
 102604041542107983E-06Cronin2008GRCh37Screening for replication of genome-wide SNP associations in sporadic ALS Eur J Hum Genet 2009 Feb;17(2):213-8 Epub 2008 Nov 5
 15423763 Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 15468466 Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 1546810090.5Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 11243339154429560.48Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 1129300154595640.49Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 22300641546676430.35Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 22933531546676280.27Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 37349601546841500.08Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 38072181544611120.14Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 38175221546726460.32Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 5609148315456118 Daoud2010GRCh37Resequencing of 29 Candidate Genes in Patients With Familial and Sporadic Amyotrophic Lateral Sclerosis
 102604041542107980.0008Del Bo2008GRCh37DPP6 gene variability confers increased risk of developing sporadic amyotrophic lateral sclerosis in Italian patients
 10260404154210798 Fogh2009GRCh37No association of DPP6 with amyotrophic lateral sclerosis in an Italian population
 102604041542107980.61Li2009GRCh37Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients
 102604041542107985.4E-08van Es2007GRCh37Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis