GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneCYP2D6
Other names"cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6",CPD6, P450-DB1, CYP2D, P450C2D
Gene namecytochrome P450, family 2, subfamily D, polypeptide 6
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryPOOR METABOLISM OF XENOBIOTICS
Chromosome22q13.1
GRCh37 (hg19)Chr22:42522501-42526883 ( -)
GRCh38 (hg38)Chr22:42126499-42130881(-)
BackgroundHypothesized poor metabolism of xenobiotics as risk factor
ResultOne reported association, not replicable
Mutations0
Patients0

BIOINFORMATICS

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Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB ALS Data Browser

ANIMAL MODELS

                               

KEY PUBLICATIONS (2)

First_AuthorYearTitlePaper
Nicholl1999A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical ParkinsonismFull_Paper
Siddons1996Debrisoquine hydroxylase gene polymorphism frequencies in patients with amyotrophic lateral sclerosisFull_Paper