GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneCNTF
Other namesHCNTF
Gene nameciliary neurotrophic factor
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome11q12
GRCh37 (hg19)Chr11:58390146-58393206 ( +)
GRCh38 (hg38)Chr11:58622673-58625733(+)
BackgroundMice lacking CNTF develop mild, progressive motor neuron loss
ResultContradictory results
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (8)

First_AuthorYearTitlePaper
Al-Chalabi2003Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosisFull_Paper
DeChiara1995Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birthFull_Paper
Giess2002Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier geneFull_Paper
Masu1993Disruption of the CNTF gene results in motor neuron degenerationFull_Paper
Orrell1995Investigation of a mutation of the CNTF gene in familial amyotrophic lateral sclerosisFull_Paper
Orrell1995Investigation of a null mutation of the CNTF gene in familial amyotrophic lateral sclerosisFull_Paper
Takahashi1994A null mutation in the human CNTF gene is not causally related to neurological diseasesFull_Paper
Takahashi1995Deficiency of human ciliary neurotropic factor (CNTF) is not causally related to amyotrophic lateral sclerosis (ALS)Full_Paper