GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneANG
Other namesRNASE5; ALS9
Gene nameangiogenin, ribonuclease, RNase A family 5
Gene inheritanceFALS genes found in SALS
Discovery methodCandidate gene
CategoryALTERED DNA/RNA PROCESSING
Chromosome14q11.1
GRCh37 (hg19)Chr14:21152336-21162345 ( +)
GRCh38 (hg38)Chr14:20684177-20694186(+)
BackgroundANG is functionally similar to VEGF
ResultAssociation found in Scottish and Irish populations
Mutations29
Patients31
FALSSALSMaleFemaleBulbarLimbNo dataMean age onsetN
822116101705530

BIOINFORMATICS

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TOP META-ANALYSIS RESULT FROM ALSGENE

For more details on this and other meta-analysis results in this region please visit the ALSGene database

ANIMAL MODELS

                               

KEY PUBLICATIONS (28)

First_AuthorYearTitlePaper
Brown2012SOD1, ANG, TARDBP and FUS mutations in Amyotrophic Lateral Sclerosis: a United States clinical testing lab experienceFull_Paper
Conforti2008A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern ItalyFull_Paper
Conforti2008A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern ItalyFull_Paper
Corrado2007Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian populationFull_Paper
Crabtree2007Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosisFull_Paper
Del Bo2008Absence of angiogenic genes modification in Italian ALS patientsFull_Paper
Fernández-Santiago2009Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosisFull_Paper
Gellera2008Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosisFull_Paper
Greenway2004A novel candidate region for ALS on chromosome 14q11.2Full_Paper
Greenway2006ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosisFull_Paper
Kirby2012Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutationFull_Paper
Luigetti2011SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variantFull_Paper
Millecamps2010SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlationsFull_Paper
Padhi2012Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosisFull_Paper
Padhi2013ANGDelMut - a web-based tool for predicting and analyzing functional loss mechanisms of deleterious angiogenin mutations causing amyotrophic lateral sclerosisFull_Paper
Padhi2013Prediction of Functional Loss of Human Angiogenin Mutants Associated with ALS by Molecular Dynamics SimulationsFull_Paper
Paubel2008Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosisFull_Paper
Seilean2009Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutationFull_Paper
Skvortsova2004Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND)Full_Paper
Subramanian2007Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neuronsFull_Paper
Takahashi2008Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosisFull_Paper
Ueki2008Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populationsFull_Paper
van Blitterswijk2012Genetic overlap between apparently sporadic motor neuron diseasesFull_Paper
van Blitterswijk2012Genetic overlap between apparently sporadic motor neuron diseasesFull_Paper
van Es2009A case of ALS-FTD in a large FALS pedigree with a K17I ANG mutationFull_Paper
van Es2011Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosisFull_Paper
Wu2007Angiogenin loss-of-function mutations in amyotrophic lateral sclerosisFull_Paper
Zou2012Identification of a novel missense mutation in angiogenin in a Chinese amyotrophic lateral sclerosis cohortFull_Paper

GENETIC VARIATIONS

SNP (rs)BasepairpvalueAuthorYearTermPaper
 11701211620530.005Conforti2008GRCh37A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy
 21161726 Conforti2008GRCh37A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy
 11701211620530.41Corrado2007GRCh37Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
 1751613321152167 Corrado2007GRCh37Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
 2858950121152604 Corrado2007GRCh37Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
 498231921152150 Corrado2007GRCh37Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
 21161931 Corrado2007GRCh37Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
 21161830 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161844 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161845 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161887 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161912 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161914 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 21161931 Crabtree2007GRCh37Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
 1170121162053 Del Bo2008GRCh37Absence of angiogenic genes modification in Italian ALS patients
 1170121162053 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21161726 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21161758 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21161784 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21161855 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21162132 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21162136 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 21162169 Gellera2008GRCh37Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis
 1170121162053 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 1170121162053 Greenway2004GRCh37A novel candidate region for ALS on chromosome 14q11.2
 21161830 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161844 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161845 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161887 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161912 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161914 Greenway2004GRCh37A novel candidate region for ALS on chromosome 14q11.2
 21161914 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 21161931 Greenway2006GRCh37ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
 1756021161973 Greenway2004GRCh37A novel candidate region for ALS on chromosome 14q11.2
 222865321162086 Greenway2004GRCh37A novel candidate region for ALS on chromosome 14q11.2
 1170121162053 Paubel2008GRCh37Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis
   Skvortsova2004GRCh37Analysis of heavy neurofilament subunit gene polymorphism in Russian patients with sporadic motor neuron disease (MND)
 21161830 Subramanian2007GRCh37Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
 21161912 Subramanian2007GRCh37Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
 21161914 Subramanian2007GRCh37Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
 21161784 Wu2007GRCh37Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis
 21161845 Wu2007GRCh37Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis
 21161878 Wu2007GRCh37Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis
 21162130 Wu2007GRCh37Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis