GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneALAD
Other names"porphobilinogen synthase"
Gene named-Aminolevulinic Acid Dehydratase
Gene inheritanceSALS genes
Discovery methodGWAS
CategoryPOOR METABOLISM OF XENOBIOTICS
Chromosome9q33.1
GRCh37 (hg19)Chr9:116148592-116163618 ( -)
GRCh38 (hg38)Chr9:113386312-113401338(-)
BackgroundLead exposure associated with ALS ALAD is involved in haem synthesis in erythrocytes
ResultNo association with human ALS demonstrated/ replicated
Mutations0
Patients0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (2)

First_AuthorYearTitlePaper
Kamel2002Lead exposure and amyotrophic lateral sclerosisFull_Paper
Kamel2003Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genesFull_Paper