ALSoD: Amyotrophic Lateral Sclerosis Online Genetics Database

ALS ONLINE GENETICS DATABASE

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ALSoD is a joint project of World Federation of Neurology and European Network to Cure ALS

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Last Update
16th May 2013

GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS

Gene	TARDBP(TDP43)
Other names	ALS10; TDP-43
Gene name	TAR DNA binding protein
Gene inheritance category	FALS genes found in SALS
Category	ALTERED DNA/RNA PROCESSING
Chromosome	1p36.22
Background	TDP43 is a human low molecular weight neurofilament mRNA-binding protein. Inclusions of TDP-43 described in MND and FTD. Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS
Result	TDP43 mutations found in FALS and SALS patients
Total Mutations	50
Total Affected	91

FALS	SALS	Male	Female	Bulbar	Limb	No data	Mean age onset	N
49	32	52	29	23	64	0	54	87

BIOINFORMATICS

Entrez Gene UCSC Browser Protein Structure OMIM Genecards Full Literature ProtScale Sequence Mutations Uniprot

iHop Pathway GeneTest ALS review Mutation Google Map Patients Gene review Species Neuromuscular

GeneMANIA AmiGO Gene Wiki Wolfram Alpha Ensembl NCBI WikiGenes Life Science DB(Japan) ALSGene GeneNetwork

KEY PUBLICATIONS (29)

First_Author	Year	Title	Paper
Bäumer	2009	TARDBP in amyotrophic lateral sclerosis: identification of a novel variant but absence of copy number variation	Full_Paper
Bäumer	2009	TARDBP in amyotrophic lateral sclerosis: identification of a novel variant but absence of copy number variation	Full_Paper
Benajiba	2009	TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration	Full_Paper
Chio	2012	ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations	Full_Paper
Corrado	2009	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis	Full_Paper
Daoud	2008	Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis	Full_Paper
Daoud	2008	Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis	Full_Paper
Del Bo	2009	TARDBP (TDP-43) sequence analysis in patients with familial and sporadic ALS: identification of two novel mutations	Full_Paper
Dickson	2007	TDP-43 in differential diagnosis of motor neuron disorders	Full_Paper
Fujita	2008	Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS	Full_Paper
Gijselinck	2008	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS	Full_Paper
Gitcho	2008	TDP-43 A315T mutation in familial motor neuron disease	Full_Paper
Guerreiro	2008	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis	Full_Paper
Kabashi	2008	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis	Full_Paper
Kamada	2009	Screening for TARDBP mutations in Japanese familial amyotrophic lateral sclerosis	Full_Paper
Kamada	2009	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis	Full_Paper
Kirby	2009	Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis	Full_Paper
Kuhnlein	2008	Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations	Full_Paper
Lagier-Tourenne	2009	Rethinking ALS: The FUS about TDP-43	Full_Paper
Larier-Tourenne	2009	Rethinking ALS: the FUS about TDP-43	Full_Paper
Lemmens	2009	TDP-43 M311V mutation in familial amyotrophic lateral sclerosis	Full_Paper
Millecamps	2010	SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations	Full_Paper
Origone	2009	Enlarging clinical spectrum of FALS with TARDBP gene mutations: S393L variant in an Italian family showing phenotypic variability and relevance for genetic counselling	Full_Paper
Pesiridis	2009	Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis	Full_Paper
Rutherford	2008	Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis	Full_Paper
Sreedharan	2008	TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis	Full_Paper
Tsai	2010	FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS	Full_Paper
van Blitterswijk	2012	Genetic overlap between apparently sporadic motor neuron diseases	Full_Paper
Van Deerlin	2008	TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis	Full_Paper
Williams	2009	A novel TARDBP mutation in an Australian amyotrophic lateral sclerosis kindred	Full_Paper
Winton	2008	A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro	Full_Paper
Winton	2009	A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro	Full_Paper
Xiong	2010	Association between novel TARDBP mutations and Chinese patients with amyotrophic lateral sclerosis	Full_Paper
Yokoseki	2008	TDP-43 mutation in familial amyotrophic lateral sclerosis	Full_Paper
Zou	2012	Screening of the TARDBP gene in familial and sporadic amyotrophic lateral sclerosis patients of Chinese origin	Full_Paper

GENETIC VARIATIONS

SNP (rs)	Basepair	pvalue	Author	Year	Term	Paper
	11082266		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082325		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082347		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082349		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082461		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082470		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082475		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082601		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082602		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082610		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11082644		Corrado	2009	GRCh37	High frequency of TARDBP gene mutations in Italian patients with amyotrophic lateral sclerosis
	11072532		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11072534		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11073982		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11074087		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11076888		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11078630		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11079042		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11080584		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11080726		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11080792		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11082106		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
	11083955		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
1474891	11081880	0.8	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
2273348	11079077		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
2273348	11079077	0.9	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
3765895	11074250	0.9	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
3765896	11074420	0.9	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
3835416	11082055		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
3835416	11082055	0.9	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
4133584	11072885		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
4133584	11072885	0.8	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
7546126	11079413	0.6	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
968545	11072579		Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
968545	11072579	0.7	Gijselinck	2008	GRCh37	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS
11121675			Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676			Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501			Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273348			Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
3765896			Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11073979		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11073982		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11076931		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11080617		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11082411		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11082522		Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10157927	10974329	0.587	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10157927	10974329	0.596	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10157927	10974329	0.705	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10157927	10974329	0.757	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10157927	10974329	0.906	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1033638	11086717	0.0491	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1033638	11086717	0.105	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1033638	11086717	0.406	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1033638	11086717	0.428	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1033638	11086717	0.509	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10864479	10968730	0.603	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10864479	10968730	0.758	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10864479	10968730	0.787	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10864479	10968730	0.807	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
10864479	10968730	0.864	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.7	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.725	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.734	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.907	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.948	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121663	11024395	0.95	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121664	11024637	0.711	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121664	11024637	0.736	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121664	11024637	0.794	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121664	11024637	0.956	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121664	11024637	0.966	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121675	11060075	0.0781	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121675	11060075	0.115	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121675	11060075	0.208	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121675	11060075	0.328	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121675	11060075	0.915	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676	11063043	0.0815	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676	11063043	0.267	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676	11063043	0.279	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676	11063043	0.427	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11121676	11063043	0.854	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.294	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.327	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.771	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.801	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.827	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
11576658	11037736	0.983	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.189	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.31	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.721	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.769	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.902	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12066915	10993727	0.963	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12121344	11111629	0.207	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12121344	11111629	0.21	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12121344	11111629	0.709	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12121344	11111629	0.964	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12711521	11090916	0.13	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12711521	11090916	0.137	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12711521	11090916	0.143	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12711521	11090916	0.344	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12711521	11090916	0.483	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501	11070652	0.066	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501	11070652	0.0688	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501	11070652	0.0813	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501	11070652	0.333	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12744501	11070652	0.474	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.293	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.4	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.407	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.503	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.639	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.772	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12748162	10986308	0.943	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12755921	11000276	0.0911	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12755921	11000276	0.329	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12755921	11000276	0.331	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12755921	11000276	0.341	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
12755921	11000276	0.409	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.201	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.683	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.687	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.716	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.763	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.948	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280970	10978810	0.986	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280972	10978062	0.617	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280972	10978062	0.624	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280972	10978062	0.642	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280972	10978062	0.914	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280972	10978062	0.949	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280975	10976695	0.6	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280975	10976695	0.603	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280975	10976695	0.636	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280975	10976695	0.653	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280975	10976695	0.755	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280984	10984562	0.258	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280984	10984562	0.439	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280984	10984562	0.594	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280984	10984562	0.614	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1280984	10984562	0.924	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.0273	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.282	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.298	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.436	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.826	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.903	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281008	11011002	0.922	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281009	11010853	0.147	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281009	11010853	0.352	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281009	11010853	0.641	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281009	11010853	0.721	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1281009	11010853	0.85	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
17036350	11171226	0.417	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1925666	10999600	0.0438	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1925666	10999600	0.224	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1925666	10999600	0.375	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1925666	10999600	0.929	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
1925666	10999600	0.933	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2003046	11032827	0.285	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2003046	11032827	0.318	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2003046	11032827	0.715	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2003046	11032827	0.891	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2003046	11032827	0.989	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273337	11141102	0.321	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273337	11141102	0.358	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273337	11141102	0.837	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273337	11141102	0.896	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273348	11079077	0.0537	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273348	11079077	0.145	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273348	11079077	0.161	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2273348	11079077	0.417	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2275525	11169676	0.417	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387422	10980998	0.236	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387422	10980998	0.707	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387422	10980998	0.749	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387422	10980998	0.919	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387422	10980998	0.94	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.127	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.499	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.679	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.751	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.771	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.875	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2387698	10992104	0.987	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2486671	10983951	0.117	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2486671	10983951	0.583	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2486671	10983951	0.688	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2486671	10983951	0.71	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2486671	10983951	0.865	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2536	11166713	0.416	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2536	11166713	0.582	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2802211	11132217	0.364	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2802211	11132217	0.757	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2802211	11132217	0.858	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
2802211	11132217	0.901	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
3765896	11074420	0.0693	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
3765896	11074420	0.154	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
3765896	11074420	0.401	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
3765896	11074420	0.409	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
4845964	10980544	0.612	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
4845964	10980544	0.802	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
4845964	10980544	0.86	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
4845964	10980544	0.898	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
4845964	10980544	0.972	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.0294	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.335	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.477	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.49	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.921	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540959	11016378	0.946	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540964	11166302	0.288	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540964	11166302	0.811	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540964	11166302	0.866	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6540964	11166302	0.9	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6656310	11002488	0.0435	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6656310	11002488	0.0554	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6656310	11002488	0.232	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6656310	11002488	0.292	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6656310	11002488	0.418	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6659231	11024353	0.67	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6659231	11024353	0.674	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6659231	11024353	0.715	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6659231	11024353	0.85	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6659231	11024353	0.96	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6704113	11053101	0.139	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6704113	11053101	0.333	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6704113	11053101	0.396	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6704113	11053101	0.76	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
6704113	11053101	0.829	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
744921	10998509	0.0518	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
744921	10998509	0.144	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
744921	10998509	0.147	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
744921	10998509	0.364	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
744921	10998509	0.933	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
7548659	11107439	0.208	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
7548659	11107439	0.376	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
7548659	11107439	0.554	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
7548659	11107439	0.74	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
7548659	11107439	0.784	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.129	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.265	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.415	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.578	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.754	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
9430161	11046855	0.953	Guerreiro	2008	GRCh37	TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis
	11078893		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082325		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082409		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082508		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082549		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082610		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082634		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11082635		Kabashi	2008	GRCh37	TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
	11078893		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082266		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082325		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082334		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082347		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082349		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082358		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082397		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082409		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082457		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082461		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082470		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082475		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082494		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082501		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082508		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082521		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082549		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082553		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082587		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082601		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082602		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082610		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082613		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082634		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082635		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11082644		Larier-Tourenne	2009	GRCh37	Rethinking ALS: the FUS about TDP-43
	11076931		Sreedharan	2008	GRCh37	TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
	11082347		Sreedharan	2008	GRCh37	TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
	11082457		Sreedharan	2008	GRCh37	TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
	11082475		Sreedharan	2008	GRCh37	TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
	11082335		Van Deerlin	2008	GRCh37	TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
	11082358		Van Deerlin	2008	GRCh37	TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
	11082494		Yokoseki	2008	GRCh37	TDP-43 mutation in familial amyotrophic lateral sclerosis