| Gene | SPAST |
| Other names | FSP2; SPG4; ADPSP; KIAA1083 |
| Gene name | spastin |
| Gene inheritance category | SALS genes |
| Category | NEUROFILAMENTS, CYTOSKELETON AND MICROTUBULE DEFECTS |
| Chromosome | 2p24 |
| Background | Mutations in spastin and paraplegin are the most common causes of hereditary spastic paraparesis |
| Result | One case reported of young onset, slowly progressive upper and lower motor neuron syndrome with spastin mutation. No association with paraplegin |
| Total Mutations | 0 |
| Total Affected | 0 |