ALS  ONLINE  GENETICS  DATABASE
You are here ==> Skip Navigation LinksHome --> Gene Overview
NEW!!! Check ALSoD on your smartphones and tablets .......... ALSoD is now Mobile-Friendly!!! .......... as usual use http://alsod.iop.kcl.ac.uk

Chromosomes

1 2 3 4 5 6 7 8 9 10
11 12 13 14 15 16 17 18 19 20
21 22 X Y ALL          

ALSoD is a joint project of World Federation of Neurology and European Network to Cure ALS. The work leading to these results has received funding from the European Community’s Health Seventh Framework Programme FP7/2007-2013 under grant agreement number 259867.
European ALS ConsortiumWorld Federation of Neurology

ALSoD is funded by
ALS AssociationALS Society of CanadaMND AssociationMND Association Iceland
Since 03/01/09
Viewed  966768  times,
Visited by
47121
Unique Users
You are accessing from
  Unknown
Last Update
22nd April 2014 


GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GenePSEN1
Other namesAD3; FAD; PS1; S182; "Alzheimer disease 3"
Gene namepresenilin 1
Gene inheritance categorySALS genes
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome14q24.3
Genomic CoordinatesChr14:73603143-73690399 ( +)
BackgroundPSEN1 involved in apoptosis, a postulated mechanism for neuronal death
ResultWeak association found, small study, not replicated
Total Mutations0
Total Affected0

BIOINFORMATICS

Entrez Gene   UCSC Browser   Protein Structure   OMIM   Genecards   Full Literature   ProtScale  Sequence    Uniprot
iHop   Pathway   GeneTest   ALS review                        Animal models
GeneMANIA   AmiGO   Gene Wiki   Wolfram Alpha   Ensembl   NCBI   WikiGenes      ALSGene      GeneNetwork
Gen2Phen   LOVD   Orphanet

ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Panas2000Genotyping of presenilin-1 polymorphism in amyotrophic lateral sclerosisFull_Paper
 
© Copyright 2007-2014 King's College London, The Institute of Psychiatry | Rewritten + Version 4.0 by Olubunmi Abel | Project coordinated by Prof Ammar Al-Chalabi