GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GenePSEN1
Other namesAD3; FAD; PS1; S182; "Alzheimer disease 3"
Gene namepresenilin 1
Gene inheritanceSALS genes
Discovery method 
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome14q24.3
Genomic CoordinatesChr14:73603143-73690399 ( +)
BackgroundPSEN1 involved in apoptosis, a postulated mechanism for neuronal death
ResultWeak association found, small study, not replicated
Total Mutations0
Total Affected0

BIOINFORMATICS

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ANIMAL MODELS

                               

KEY PUBLICATIONS (1)

First_AuthorYearTitlePaper
Panas2000Genotyping of presenilin-1 polymorphism in amyotrophic lateral sclerosisFull_Paper