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ALSoD is a joint project of World Federation of Neurology and European Network to Cure ALS. The work leading to these results has received funding from the European Community’s Health Seventh Framework Programme FP7/2007-2013 under grant agreement number 259867.
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GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneMAPT
Other namesTAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549
Gene namemicrotubule-associated protein tau
Gene inheritance categorySALS genes
CategoryNEUROFILAMENTS, CYTOSKELETON AND MICROTUBULE DEFECTS
Chromosome17q21
Genomic CoordinatesChr17:43971748-44105700 ( +)
BackgroundMicrotubule-associated protein tau involved in other neurodegenerative diseases and Guam variant of ALS has neurofibrillary tangles containing aggregates of tau
ResultAssociation reported but p values were weak
Total Mutations0
Total Affected0

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ANIMAL MODELS

                               

KEY PUBLICATIONS (4)

First_AuthorYearTitlePaper
Boeve2012Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72Full_Paper
Froelich1997Mapping of a disease locus for familial rapidly progressive frontotemporal dementia to chromosome 17q12-21 Full_Paper
Kowalska2003Familial amyotrophic lateral sclerosis and parkinsonismdementia complex-tauopathy without mutations in the tau gene?Full_Paper
Poorkaj2001TAU as a susceptibility gene for amyotropic lateral sclerosisparkinsonism dementia complex of GuamFull_Paper
 
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