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ALSoD is a joint project of World Federation of Neurology and European Network to Cure ALS. The work leading to these results has received funding from the European Community’s Health Seventh Framework Programme FP7/2007-2013 under grant agreement number 259867.
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GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneHFE
Other namesHH; HFE1; HLA-H; MGC103790; dJ221C16.10.1
Gene nameHH; HFE1; HLA-H; MGC103790; dJ221C16.10.1
Gene inheritance categorySALS genes
CategoryOXIDATIVE STRESS
Chromosome6p21.3
Genomic CoordinatesChr6:26087509-26095469 ( +)
BackgroundOxidative stress is hypothesized to be implicated in neurodegeneration and misregulation of iron induces oxidative stress. Also, abnormal iron levels found in spinal cords of ALS patients
ResultContradictory results
Total Mutations0
Total Affected0

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ANIMAL MODELS

                               
ALSGene: A database for amyotrophic lateral sclerosis genetic association studies developed by the Max Planck Institute for Molecular Genetics Berlin, the Alzheimer Research Forum and Prize4Life.  Last Update: 14th August 2011

KEY PUBLICATIONS (6)

First_AuthorYearTitlePaper
Goodall2005Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALSFull_Paper
He2010H63D polymorphism in the hemochromatosis gene is associated with sporadic amyotrophic lateral sclerosis in ChinaFull_Paper
Restagno2007HFE H63D polymorphism is increased in patients with amyotrophic lateral sclerosis of Italian originFull_Paper
Sutedja2007The association between H63D mutations in HFE and amyotrophic lateral sclerosis in a Dutch populationFull_Paper
Wang2004Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequencesFull_Paper
Yen2004HFE mutations are not strongly associated with sporadic ALSFull_Paper
 
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