ALSoD: Amyotrophic Lateral Sclerosis Online Genetics Database

ALS ONLINE GENETICS DATABASE

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ALSoD is a joint project of World Federation of Neurology and European Network to Cure ALS

ALSoD is funded by

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GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS

Gene	GARS
Other names	HMN5; CMT2D; DSMAV; GlyRS; SMAD1
Gene name	glycyl-tRNA synthetase
Gene inheritance category	SALS genes
Category	ALTERED DNA/RNA PROCESSING
Chromosome	7p15
Background	Mutated in distal hereditary motor neuropathy type V. Role for tRNA-charging enzymes in peripheral axons.
Result	Not yet tested in SALS, but an interesting candidate
Total Mutations	0
Total Affected	0

BIOINFORMATICS

Entrez Gene UCSC Browser Protein Structure OMIM Genecards Full Literature ProtScale Sequence Uniprot

iHop Pathway GeneTest ALS review

GeneMANIA AmiGO Gene Wiki Wolfram Alpha Ensembl NCBI WikiGenes GeneNetwork

KEY PUBLICATIONS (2)

First_Author	Year	Title	Paper
Antonellis	2006	Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons	Full_Paper
Dubourg	2006	The G526R glycyl-tRNA synthetase gene mutation in distal hereditary motor neuropathy type V	Full_Paper

GENETIC VARIATIONS

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