GENE OVERVIEW OF KEY PUBLISHED STUDIES FOR ALS


GeneAPOE
Other namesAD2; LPG; MGC1571; apoprotein
Gene nameapolipoprotein E
Gene inheritance categoryPhenotype-modifying genes
CategoryREGENERATION, TROPHISM AND MOTONEURONAL DEATH
Chromosome19q13.2
Genomic CoordinatesChr19:45409039-45412650 ( +)
BackgroundImplicated in several other neurodegenerative disorders
ResultNot associated with susceptibility. May be associated with age of onset, presentation and survival
Total Mutations0
Total Affected0

BIOINFORMATICS

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iHop  Pathway  GeneTest  ALS review                  Animal models
GeneMANIA  AmiGO  Gene Wiki  Wolfram Alpha  Ensembl  NCBI  WikiGenes  Life Science DB(Japan)  ALSGene    GeneNetwork
Gen2Phen   LOVD   Orphanet Human Proteome Map Proteomics DB

TOP META-ANALYSIS RESULT FROM ALSGENE

For more details on this and other meta-analysis results in this region please visit the ALSGene database

ANIMAL MODELS

                               

KEY PUBLICATIONS (13)

First_AuthorYearTitlePaper
Al-Chalabi1996Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron diseaseFull_Paper
Bachus1997Lack of association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron diseaseFull_Paper
Drory2001Association of APOE epsilon4 allele with survival in amyotrophic lateral sclerosisFull_Paper
Gaillard1998Apolipoprotein E and multiple sclerosis: a biochemical and genetic investigationFull_Paper
Haasdijk2002Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 miceFull_Paper
Lacomblez2002APOE: a potential marker of disease progression in ALSFull_Paper
Li2004Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosisFull_Paper
Moulard1996Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosisFull_Paper
Mui1995Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosisFull_Paper
Penco2008New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic backgroundFull_Paper
Schmidt2010Association of ALS with head injury, cigarette smoking and APOE genotypesFull_Paper
Siddique1998Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosisFull_Paper
Zetterberg2008Association of APOE with age at onset of sporadic amyotrophic lateral sclerosisFull_Paper